Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

JB Pingault, AG Allegrini, T Odigie… - Journal of Child …, 2022 - Wiley Online Library
… associations between child polygenic scores and environmental exposures can exist …
environment correlations; and (c) adjusting an exposure-outcome association for a polygenic score

A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation

R Avinun, AR Hariri - Journal of psychiatric research, 2019 - Elsevier
… a certain reaction from the environment, may be relevant to weight-… In the current study, we
hypothesized that a polygenic score … we also used BMI polygenic scores that were based on a …

[HTML][HTML] Polygenic scores: prediction versus explanation

R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
… –environment (GE) correlation and … environments correlated with their genetic propensities.
For example, parents with high polygenic scores for EA not only transmit high EA scores to …

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

R Plomin, A Gidziela, M Malanchini… - Development and …, 2022 - cambridge.org
scores) that are powerful predictors of behavioral traits. Here, we test the extent to which
polygenic scores … between parent reports of their children’s environmental risk (E) at ages 3 and …

Commentary: Missing heritability, polygenic scores, and gene–environment correlation

R Plomin - Journal of Child Psychology and Psychiatry, 2013 - Wiley Online Library
… In the first developmental study using polygenic scores, a polygenic score for 5 SNPs …
between the polygenic score and IQ at age 7 was stronger in low-risk environments (Harlaar et al., …

Polygenic scores for plasticity: A new tool for studying gene–environment interplay

R Johnson, R Sotoudeh, D Conley - Demography, 2022 - read.dukeupress.edu
… × environment (G×E) research deploys a limited toolkit on the genetic side to study the
gene–environment interplay, relying on polygenic scores (… : variance polygenic scores (vPGSs), …

Widespread covariation of early environmental exposures and trait-associated polygenic variation

E Krapohl, LJ Hannigan, JB Pingault… - Proceedings of the …, 2017 - National Acad Sciences
… To estimate the univariate effect of each polygenic score on the environmental exposures, …
Findings illustrate the relevance of gene–environment correlation for polygenic prediction …

[HTML][HTML] Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

K Bolhuis, LR Steenkamp, LME Blanken… - European child & …, 2022 - Springer
… Only a few studies have employed schizophrenia polygenic risk scores to study the possibility
of such gene–environment correlations. Increased schizophrenia polygenic risk has been …

[HTML][HTML] Comparing within-and between-family polygenic score prediction

S Selzam, SJ Ritchie, JB Pingault, CA Reynolds… - The American Journal of …, 2019 - cell.com
… , assortative mating, and environmentally mediated parental genetic effects, a form of
genotype-environment correlation (rGE). Comparing genome-wide polygenic score (GPS) …

Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: Evidence of gene–environment correlation

S Machlitt‐Northen, R Keers, PB Munroe… - Journal of Child …, 2022 - Wiley Online Library
… whether patterns of gene–environment correlations differ between SCZ and MDD… correlations
between polygenic scores (schizophrenia and depression) and established environmental