[HTML][HTML] A comprehensive assessment of phytochemicals from Phyla nodiflora (L.) Greene as a potential enzyme inhibitor, and their biological potential: An in-silico, in …

A Alafnan, MF Nadeem, SF Ahmad, M Sarfraz… - Arabian Journal of …, 2023 - Elsevier
… /g extract) enzyme inhibition activity. … enzymes was highlighted by molecular docking
studies. In sum, this research showed that the studied extracts were effective as enzyme inhibitors

[图书][B] Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists

RA Copeland - 2013 - books.google.com
… converting enzyme inhibitors shifted the balance of treatment modalities towards enzyme
inhibitors … Therefore, careful, quantitative assessment of compound interactions with metabolic …

A comprehensive guide for assessing covalent inhibition in enzymatic assays illustrated with kinetic simulations

E Mons, S Roet, RQ Kim, MPC Mulder - Current protocols, 2022 - Wiley Online Library
… the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby
… to assess the biochemical potency of (ir)reversible covalent enzyme inhibitors targeting a …

Prediction of severity of drug-drug interactions caused by enzyme inhibition and activation

A Dmitriev, D Filimonov, A Lagunin, D Karasev… - Molecules, 2019 - mdpi.com
inhibiting and/or inducing the metabolism or transporter-mediated disposition of the victim
drug. Accurate assessment … A comprehensive description of the methods for DDIs prediction is …

[图书][B] The inhibitor index: a desk reference on enzyme inhibitors, receptor antagonists, drugs, toxins, poisons, biologics, and therapeutic leads

D Purich - 2017 - taylorfrancis.com
… MAKING BEST USE OF THE INHIBITOR INDEX – Experiments with enzyme inhibitors
and receptor antagonists are least ambiguous when researchers maximize target specificity/…

Neurotoxicity assessment of four different pesticides using in vitro enzymatic inhibition assays

C Martins-Gomes, TE Coutinho, TL Silva, T Andreani… - Toxics, 2022 - mdpi.com
… analyzed in this study that inhibited both enzymes, AChE and BChE. At 500 µM, IMZ inhibited
AChE activity by about 48%, being this the higher inhibition value obtained (Figure 3A). As …

Recent advances in enzyme inhibition based-electrochemical biosensors for pharmaceutical and environmental analysis

J Li, H Chang, N Zhang, Y He, D Zhang, B Liu, Y Fang - Talanta, 2023 - Elsevier
… and detection of enzymatic inhibitors owing to their low-cost, … a comprehensive overview
of the current status of enzyme … of DON and BER to inhibit AChE being assessed through the …

… of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on angiotensin-converting enzyme 2 levels: a comprehensive analysis based on …

G Kriszta, Z Kriszta, S Vancsa, PJ Hegyi… - Frontiers in …, 2021 - frontiersin.org
… Three studies assessed the influence of RAS inhibitors on ACE2 expression under
physiological conditions. Following 12-days long oral administration, lisinopril or losartan elevated …

A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

C Säll, JB Houston, A Galetin - Drug Metabolism and Disposition, 2012 - ASPET
… Involvement of aldehyde oxidase and aldehyde dehydrogenase in the second formation
step of M2 was investigated by assessing the effect of known inhibitors of these enzymes, …

Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors

VW Byrnes, VV Sardana, WA Schleif… - Antimicrobial agents …, 1993 - Am Soc Microbiol
assessments of mutant virus than thoseof mutant enzyme (… inhibitor interacts in a unique
way with the enzyme's inhibitor-… profiles established for each individual inhibitor may help in …