… Drugs that function as enzyme inhibitors … of drug discovery and development efforts at
present are focused on identifying and optimizing drug candidates that act through inhibition of …

… a continued expansion of interest in the quantitative evaluation of enzyme inhibitors for the
applied sciences of drug discovery and drug development. While this time period has seen …

… The detailed characterization of irreversible enzyme inhibitors in drug discovery programs
is beyond the scope of this article, but excellent accounts in literature provide guidance to …

… in enzyme inhibition as applied to drug discovery and drug … pharmacokinetic aspects of
enzyme inhibition, with chapters … of the drug discovery processes, including chapters on drug …

… modulate the activity of enzymes, which in … enzyme inhibitor-based drug discovery lies in
the development of more selective and potent inhibitors, as well as the ability to target enzymes …

… throughout the drug development process. … drug–drug interaction risks by enzyme inhibition
and lays particular emphasis on in vitro study designs and interpretation of CYP inhibition …

… However, the inhibition of diverse enzymes for the better … that showed inhibition toward
several enzymatic targets with author’… the perspective of enzyme inhibitory activities, rationalizing …

Support Vector Machines (SVM) is a powerful classification and regression tool that is becoming
increasingly popular in various machine learning applications. We tested the ability of …

… enzyme inhibitors, as exemplified by kinase inhibitors in oncology, a major focus of
current drug-discovery and development efforts is on enzyme … the course of an enzyme-catalysed …

… in vitro assessment of CYP reversible and time-dependent inhibition throughout the earlier
stages of drug Discovery and into drug Development are highlighted. In addition, the use of …