Epigenetic clocks”: Theory and applications in human biology

CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
epigenetic clocks. The goal of this review is to highlight some of the ways that epigenetic
clocks can inform questions in human biology, and vice versa, and to provide human biologists

Epigenetic clocks

EE Guevara, RR Lawler - Evolutionary Anthropology: Issues …, 2018 - Wiley Online Library
… to biological age, epigenetic clocks are … at biological age using epigenetic clocks. The most
widely used method is to look at deviations around the regression line in the epigenetic clock

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
… We aimed to develop a novel epigenetic clock that performs optimally in human cortex …
with biological ageing in the brain. We generated an extensive dataset of human cortex DNA …

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Q Zhang, CL Vallerga, RM Walker, T Lin, AK Henders… - Genome medicine, 2019 - Springer
… This study indicates that the epigenetic clock can be improved by increasing the training
sample size and that its association with mortality attenuates with increased prediction of …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
human epigenetic clocksepigenetic clocks. Subsequently, we created an extensive dataset
of over 1300 study findings in which epigenetic clocks were utilized in blood tissue of human

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
… A recent review of six types of potential biological age estimators — epigenetic clocks, …
concluded that the epigenetic clock is the most promising molecular estimator of biological age 15 …

The epigenetic clock and aging

K Raj - Epigenetics of aging and longevity, 2018 - Elsevier
biology of the bodies of women, their epigenetic clocks were acutely in tune with their
biology. … Another route by which human biology can be greatly affected is through infection. …

Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data

RE Marioni, M Suderman, BH Chen… - The Journals of …, 2019 - academic.oup.com
… the epigenetic clock from a longitudinal perspective by analysing data from five prospective
cohorts with repeated sampling. We showed that epigenetic … on the epigenetic clock in other …

Epigenetic age acceleration: a biological doomsday clock for cardiovascular disease?

MM Mendelson - Circulation: Genomic and Precision Medicine, 2018 - Am Heart Assoc
… by observations that higher epigenetic age acceleration is … of epigenetic age acceleration,
linked to telomerase biology, is … epigenetic age acceleration and broke down the epigenetic

An epigenetic clock for human skeletal muscle

S Voisin, NR Harvey, LM Haupt… - Journal of cachexia …, 2020 - Wiley Online Library
… of human skeletal muscle DNA methylation profiles, we can develop a muscle-specific epigenetic
clock that outperforms the pan-tissue clock … data to estimate epigenetic age in a total of …