… circulating metabolites on multivariate longevity and epigenetic aging, we performed a
metabolome-wide MR analysis of 249 circulating metabolites 26 on our aging-related phenotypes …

… landscape alterations in chronological aging and pro-longevity models. … WITH AGING
AND IN LONGEVITY MODELS In this review, we chose to compare age-related and longevity-…

… Increasing evidence suggests a central role of epigenetic mechanisms (heritable alterations
… studies, indicating that lifespan and longevity-associated characteristics can be transmitted …

Our understanding of the process of autophagy and its role in health and diseases has grown
remarkably in the last two decades. Early work established autophagy as a general bulk …

… and energy metabolism cell cycle, cellular senescence reflecting degenerative aging
processes. Epigenetic mechanisms, including imprinting, have been shown to be associated with …

… This review describes the epigenetic regulation of … epigenetic marks, trimethylated lysine 4
of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity. …

… The relation between the effect of genetic variation and epigenetics should also be
considered. The genetics underlying longevity have been widely explored [12, 13], but non-genetic …

… In this review we focus on recently identified mechanisms influencing longevity, aiming to …
lifespan, as well as the evolving concepts and new challenges pertinent to aging research. …

… , the review explores the epigenetic changes that occur with aging, including … aging process
and underscores the need for continued research into these complex biological mechanisms…

… Consequently, elimination of diseases could be achieved without intervention in the basic
mechanisms of aging and longevity. Another “popular” conclusion of this concept is that …