Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

I Weissberg, L Wood, L Kamintsky, O Vazquez… - Neurobiology of …, 2015 - Elsevier
… role of blood–brain barrier dysfunction in PIE, demonstrating that exposure of brain tissue
to … /TGF-β-pathway induces excitatory, but not inhibitory, synaptogenesis that precedes the …

Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
… , neuroinflammation, increasing neural excitability, reduction of seizure threshold,
excitatory synaptogenesis, impaired plasticity, and epileptogenesis. A key signaling pathway …

Blood-brain barrier dysfunction in disorders of the developing brain

R Moretti, J Pansiot, D Bettati, N Strazielle… - Frontiers in …, 2015 - frontiersin.org
… After an insult, excitatory amino acid neurotransmitters are released, causing reactive …
developmental period in human brains (ie, maximal brain growth, synaptogenesis, and myelination…

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis

G Bar-Klein, S Lublinsky, L Kamintsky, I Noyman… - Brain, 2017 - academic.oup.com
… confirm blood–brain barrier dysfunction and neuroinflammation. … Our results show that early
blood–brain barrier pathology in … We suggest quantitative assessment of blood–brain barrier

Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition …

K Lippmann, L Kamintsky, SY Kim… - Journal of Cerebral …, 2017 - journals.sagepub.com
… peri-ischemic blood–brain barrier dysfunction that included the … We conclude that blood-brain
barrier dysfunction in the peri-… , reduced inhibition and excitatory synaptogenesis 55 ; (3) …

Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
… in brain glutamate levels may lead to barrier dysfunction [21,36]. A … , contributing to barrier
dysfunction [37]. MMPs likely affect … further associated with synaptogenesis and neuroplasticity …

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

H Son, S Kim, D Jung, JH Baek, DH Lee, GS Roh… - Scientific reports, 2019 - nature.com
… Specifically, most excitatory synapses in the rodent brain are … roles of astrocytes in excitatory
synapse formation 5 . … , contacting the blood-brain barrier, and ensheathing neuronal …

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

CM Henstridge, M Tzioras… - Frontiers in cellular …, 2019 - frontiersin.org
… synaptic dysfunction. Here, we review the recent literature on the contribution of glia to
excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. …

Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by inflammatory cytokines and correlate with paralysis severity during …

PK Blakely, S Hussain, LE Carlin, DN Irani - Frontiers in neuroscience, 2015 - frontiersin.org
… MRI scans obtained following the intravenous infusion of a paramagnetic contrast material
also reveal active blood-brain barrier (BBB) breakdown in white matter plaques, and clinical-…

Synaptic elimination in neurological disorders

PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
… via processes termed synaptogenesis and synaptic pruning, … , associated with blood-brain
barrier disruption, leading to massive in… While SPARCL1 promotes the formation of excitatory