… class I surface expression. Thus, cells with a defective MHC class I antigen processing and
… be identified by measuring the MHC class I surface expression, which can be either down-…

… 1), any defect, which impairs the transport of peptides, results in reduced surface
expression of MHC class I molecules. MHC class I heterotrimers consist of a MHC encoded …

… lumen of the ER by the transporters associated with antigen processing (TAP) where they …
were then expressed along with rat TAP1 and assayed for peptide transport using iodinated …

… Interestingly, when the N- and C-terminal halves of these monomeric transporters are
expressed as separate polypeptides, they dimerize and form a functional complex (46). …

… for the essential function of the peptide transporter for antigen processing was found. Isolation
and … of substrate recognition and transport as well as the structure of the ABC transporter. …

… HLA HLA-B antigen expression on the HCC cell lines, cells expression is a loss of the TAP
transporter genes neceswere stained with anti-Bw4 and anti-Bw6 antibodies, sary for loading …

… class I antigen loss … expression of other components of the antigenprocessing machinery
in breast carcinoma lesions. Therefore, in the present study we have analyzed the expression …

… Antigen presentation by the HLA molecules to circulating CTLs requires the transporter
associated with antigen processing (TAP). Endogenous proteins (viral or tumour associated …

… information exists about the HLA class I antigen and APM component expression in surgically
removed RCC lesions. Reduced HLA class I antigen expression has been reported in ∼38…

… presentation in the context of MHC class I antigens due to defects in the antigen … study
examines the expression of HLA, tapasin, transporter associated with antigen processing 1 (TAP1)…