Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs–EVOLVE …

AKA Silva, M Morille, M Piffoux, S Arumugam… - Advanced Drug Delivery …, 2021 - Elsevier
… Based on complementary scientific, technical, and medical expertise, we provide EV-specific
recommendations for manufacturing, quality control, analytics, non-clinical development, …

[HTML][HTML] Methods of the large-scale production of extracellular vesicles

V Syromiatnikova, A Prokopeva… - International Journal of …, 2022 - mdpi.com
… the quality control of EV-like biomimetic vesicles must be extremely strict. In our opinion, such
quality control … , and nucleic acids to control biomimetic vesicles composition and the test of …

Scaled preparation of extracellular vesicles from conditioned media

S Staubach, FN Bauer, T Tertel, V Börger… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are … and
downstream processing and the subsequent quality control, each of them containing several …

Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration

JA Welsh, E van der Pol, BA Bettin… - … Extracellular Vesicles, 2020 - Taylor & Francis
… performance using quality controls. … Quality control can be assessed intra-assay with replicate
samples or inter-assay with calibration or validation reference materials. Quality control for …

[HTML][HTML] Perspectives and challenges in extracellular vesicles untargeted metabolomics analysis

D Dudzik, S Macioszek, W Struck-Lewicka… - TrAC Trends in …, 2021 - Elsevier
… The quality control assessment for metabolomics workflow should be incorporated. … In
this review, we summarize the current knowledge on extracellular vesicles and highlight their …

Toward standardization of mesenchymal stromal cell‐derived extracellular vesicles for therapeutic use: A call for action

S Roura, A Bayes‐Genis - Proteomics, 2019 - Wiley Online Library
Extracellular vesicles (EVs), which include a variety of nano‐sized membrane‐encapsulated
particles, are released to the extracellular microenvironment by the vast majority of cells …

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

A Clayton, D Buschmann, JB Byrd… - … extracellular vesicles, 2018 - Wiley Online Library
… EV, EV-like particle or an artificial vesicle-mimic that is fully … means of achieving this kind of
quality control. It requires some detailed … and methods of quality control and assurance of the …

Determination of variability due to biological and technical variation in urinary extracellular vesicles as a crucial step in biomarker discovery studies

E Oeyen, H Willems, R 'T Kindt, K Sandra… - … extracellular vesicles, 2019 - Taylor & Francis
… The raw data and identifications underwent a quality control analysis using an in-house
developed software in R to check if all samples … All samples passed the quality control analysis. …

[HTML][HTML] Removal of platelets from blood plasma to improve the quality of extracellular vesicle research

B Bettin, A Gasecka, B Li, B Dhondt, A Hendrix… - Journal of Thrombosis …, 2022 - Elsevier
… cytometry measurements based on quality control. The total … Suggested quality control
parameters include measurements of … the platelet concentration as a quality control parameter. …

Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-) analytical variables

E Geeurickx, L Lippens, P Rappu, BG De Geest… - Nature protocols, 2021 - nature.com
control or it can be used as a scaling factor for data normalization. Alternatively, a reference
material can be used as an external control … reference materials, quality control materials and …