Human umbilical cord mesenchymal stem cell‐derived extracellular vesicles: A novel therapeutic paradigm

H Abbaszadeh, F Ghorbani… - Journal of cellular …, 2020 - Wiley Online Library
… are largely dependent on paracrine factors including extracellular vesicles (EVs). EVs are
… on the use of EVs derived from human umbilical cord MSCs (hucMSCs) as a therapeutic …

[HTML][HTML] Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

E Rohde, K Pachler, M Gimona - Cytotherapy, 2019 - Elsevier
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) may deliver …
discuss strategies of manufacturing and quality control of umbilical cord–derived MSC-EVs. We …

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

RMS Cardoso, SC Rodrigues, CF Gomes… - Stem cells …, 2021 - academic.oup.com
… isolation of small extracellular vesicles (sEVs) from umbilical cord blood mononuclear cells
(… molecules to promote angiogenesis and extracellular remodeling, and to accelerate skin …

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

W Nassar, M El-Ansary, D Sabry, MA Mostafa… - Biomaterials …, 2016 - spj.science.org
… Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new
promising … Two doses of MSC-derived extracellular vesicles had been administered to patients of …

Extracellular vesicles from human umbilical cord mesenchymal stem cells facilitate diabetic wound healing through MiR-17-5p-mediated enhancement of …

Q Wei, Y Wang, K Ma, Q Li, B Li, W Hu, X Fu… - Stem cell reviews and …, 2022 - Springer
Extracellular vehicles (EVs) are considered potential therapeutic tools to promote diabetic
… The aim of this study was to investigate the effects of EVs secreted by human umbilical cord

Comparison of curative effect of human umbilical cord-derived mesenchymal stem cells and their small extracellular vesicles in treating osteoarthritis

S Tang, P Chen, H Zhang, H Weng, Z Fang… - … journal of …, 2021 - Taylor & Francis
… Citation8 Among the various sources of MSCs, the human umbilical cord among … extracellular
vesicles (sEVs). Citation12 sEVs are bilipid and nano-sized (<200 nm) membrane vesicles

[HTML][HTML] Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury

X Zhai, K Chen, H Yang, B Li, T Zhou, H Wang… - Journal of …, 2021 - Springer
Extracellular vesicles have been designed as nano drug … We aimed to construct CD73
modified extracellular vesicles … , extracellular vesicles derived from human umbilical cord MSCs (…

Comprehensive miRNA analysis of human umbilical cord-derived mesenchymal stromal cells and extracellular vesicles

X Zou, Y Yu, S Lin, L Zhong, J Sun, G Zhang… - Kidney and Blood …, 2018 - karger.com
… of factors including extracellular vesicles (EVs), which are composed of micro-vesicles and
… Methods: MSCs were cultured from the human umbilical cord, and EVs were isolated from …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410

L Dong, Y Pu, L Zhang, Q Qi, L Xu, W Li, C Wei… - Cell death & …, 2018 - nature.com
… Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) …
Then, we observed that hUCMSC-derived extracellular vesicles (hUCMSC-EVs) contribute …

[HTML][HTML] Toxicological profile of umbilical cord blood-derived small extracellular vesicles

SC Rodrigues, RMS Cardoso, CF Gomes, FV Duarte… - Membranes, 2021 - mdpi.com
… In this study, EV isolated from human umbilical cord blood mononuclear cells (UCB-MNC)
through a clinically transferable process were tested for their toxicity in vitro and in vivo. As …