… of gilteritinib resistance to the FLT3-F691L mutation. The simulations revealed that the resistant
… phosphate-binding loop, and the helix αC of the FLT3 protein. The binding abilities of the …

… gilteritinib is active against FLT3 NC and TKI resistance-causing mutations in vitro. A mutagenesis
screen identified FLT3 F691L… inhibit FLT3-ITD/F691L to a degree comparable to FLT3-…

… of gilteritinib resistance, but only a small number-all F691L-are new FLT3 mutations.
Cytogenetic clonal evolution during gilteritinib occurs commonly but is not always associated with …

… the novel FLT3 N701K mutation in addition to the FLT3 F691L gatekeeper mutation. …
gilteritinib binding to FLT3, similar to the gatekeeper F691L, and promotes resistance to gilteritinib. …

… on gilteritinib, Ras/mitogen-activated protein kinase (MAPK) pathway and FLT3 F691L gene
mutations were the most common mutational events associated with treatment resistance. …

… mediates secondary resistance to gilteritinib in patients with FLT3 mut+ R/… FLT3 mut+ R/R
AML who relapsed on gilteritinib therapy, Ras/MAPK pathway gene mutations and FLT3 F691L …

… F691L accounted for only in a minority of resistance cultures … To test if FLT3 signaling was
important for resistance, we … of gilteritinib, which have been shown to partly overcome F691L, …

… %) gilteritinib-resistant patients, FLT3 mutations were not observed in AML cells after the
gilteritinib … mutation (F691L) in FLT3, which confers resistance to all existing FLT3 inhibitors, it is …

… of Gilteritinib is unclear. In the Admiral trial, patients who received 120-mg/day Gilteritinib had
a similar incidence of FLT3 F691L … 20 to 200 mg/day Gilteritinib, while none of the patients …

… -site FLT3 mutations that conferred resistance (meaning a … 5: FLT3-TKD mutations confer
resistance to type II FLT3 … as FLT3-ITD and FLT3-TKD variants, including the F691L gatekeeper …