… In particular, some of them on FLT3, 43–45 … of FLT3. In this study, we have used molecular
dynamics simulations to highlight the effect of ITDs on the conformation and dynamics of FLT3 …

… A crystallographic study revealed that the drug bound the inactive conformation of FLT3,
at … Such changes may be evident already from the crystal structure of the apo- and holo-protein…

… changes in kinase domain of FLT3 that occur upon receptor activation are illustrated. The
active conformation of FLT3 is … to FLT3, the kinase domain adopts an inactive conformation …

… loop of the FLT3 receptor confers conformational changes in its structure, altering the
functioning of its activation loop. This results in ligand-independent FLT3-mediated constitutive …

… FLT3 inhibitors, targeting both FL and FLT3 kinase, might be more effective approach in AML
treatment. Here, we summarize up-to-date studies on FLT3 … to the conformational changes …

… Mutations in Fetal Liver Tyrosine Kinase 3 (FLT3) genes are implicated in the constitutive …
insights on the conformational changes in the mutant (D835N) structure of FLT3 protein. Our …

… The effect of insertions on the sensitivity of FLT3 to kinase … as characterized by their
conformational energy landscapes. … The changes were more pronounced than those observed …

… kinases 31 . After stimulation with FLT3L, membrane-bound FLT3 quickly changes conformation…
Dimerization stabilizes this conformational change, which further enhances activation of …

… between different conformational states in the split kinase domain of wt-Flt-3 and wt-c-Kit are
… These changes suggest that the loop becomes more flexible upon mutation. Not only is the …

… to activate the kinase by mediating conformational changes [18]. … conformation [19,21]. In
EGFR-dependent cancer cells, oxidation of Cys797 also causes relative resistance to kinase …