… domain, resulting in the constitutive activation of FLT3. Point mutations at aspartate 835
within the activation loop of the FLT3 kinase domain … of FLT3 comprised of the kinase domain (…

… acid stretch of the juxtamembrane domain of FLT3 (FLT3-JM-PMs). Expression of 4 FLT3-JM-…
(Left) Ribbon model of the crystal structure of the FLT3 kinase domain (Protein Data Bank […

… strength of the catalytic domain. This review discusses the … of differential Flt3 signaling based
on mis-localized juxtamembrane … domains to the dimeric Flt3 ligand, the intracellular kinase …

… In this study, we elucidated the role of the JM domain in FLT3 activation. Mutant FLT3 with …
The present study, further, demonstrated that the truncated FLT3/ITD lacking a kinase domain …

… JM region, phosphorylation of these tyrosine residues would prevent a JM segment from
binding to a sequence within the catalytic domain and thereby induce Flt3 kinase activity. It is …

… The ITDs occur mainly in the juxtamembrane domain of … FLT3 and six mutants by molecular
dynamics simulations. The catalytic activity of FLT3 is exerted by the tyrosine kinase domain (…

… In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of the juxtamembrane
(JM) of FLT3 have been shown to play a crucial role in driving proliferation and survival of …

… Deletion of the juxtamembrane domain … kinase I domain of FLT3 completely abolished
these phosphorylations. Our data indicate that the juxtamembrane domain of FLT3 in ETV6/FLT3 …

… In order to investigate autophosphorylated tyrosine residues in the juxtamembrane region
of Flt3 (aa's 572-603) we labeled Flt3-PAE cells with [ 32 P]orthophosphate, isolated Flt3 after …

… of the kinase domain is … the kinase domain to catalyze the transfer of a phosphate group
from adenosine triphosphate (ATP) to tyrosine residues in the juxtamembrane segment of FLT3 […