… with previous estimates obtained for other kinases. Finally, we identified FLT3 intermediates
that assumed configurations that resemble that of the c-Src nonreceptor tyrosine kinase. The …

… and signaling we analyzed eight different FLT3 mutations: Three different FLT3-ITD constructs,
FLT3-… FLT3-TKD mutants showed intermediate response , whereas no effect was seen in …

… (22.1%), and these mutations were highly enriched in a group of patients with an intermediate-risk
cytogenetic profile as well as FLT3 mutations (25 of 61 patients, 41.0%; P < 0.003) [6]. …

… Phosphorylated FLT3 activates multiple intracellular signaling pathways … FLT3-ITD high
with wild type NPM1 and FLT3-ITD low with mutated NPM1 are classified as intermediate…

… of Flt3 tyrosine kinase activity have the potential to suppress aberrant Flt3 signaling. … that
this form represents an intermediate form containing high-mannose Nlinked sugars [13, 14]. …

… , but in the case of Flt3, the most common alterations … Flt3 signaling has also revealed the
complexity of these receptor systems. The impact of gain-of-function mutations of c-Kit and Flt3 …

… Since the DNA corresponding to D593 to K602 of FLT3 potentially forms a palindromic
intermediate, a hairpin formation of a lagging strand and replication slippage might generate ITD …

… through phosphorylation downstream of FLT3 activation, as mentioned above. Specific …
FLT3 signaling. More work remains to elucidate the complete signaling pathway altered by FLT3 …

… in the FLT3 receptor tyrosine kinase … FLT3 signaling in vivo. Here we will review results
from preclinical studies and early clinical trials evaluating both first- and second-generation FLT3 …

… For intermediate and poor prognosis patients (including FLT3 mutant patients) that achieve
complete remission (CR), allogeneic hematopoietic stem cell transplant (alloHSCT) leads to …