… mutation was not detected in the extracellular part of FLT3.The recent study on the kinase …
exhibited dramatically reduced EGF binding but enhanced kinase activity. In conmatched to …

… length tandem duplication at the beginning of JM domain, at which the ITD mutation has not
been found in clinical samples, in the 4F-FLT3 construct (4F-FLT3/… FLT3/ITD lacking a kinase …

… Characterization of the protein encoded by the flt3 (flk2) receptorlike tyrosine kinase gene. …
Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibro…

… FLT3 internal tandem duplications (FLT3-ITDs) in approximately 30%, 1-3 point mutations
within the activation loop of the second tyrosine kinase domain (FLT3… mutations are FLT3-ITDs …

… kinase (FLT3) gene aberrations, internal tandem duplication (ITD) and tyrosine kinase …
studies that provided survival information according to the FLT3 status: ITD, TKD mutation, and …

… kinase 3 (FLT3) is one of the most prevalent findings in this heterogeneous disease. The major
types of mutations in FLT3 can be categorized as internal tandem duplications … the kinase …

… The type III receptor tyrosine kinase (RTK) Flt3 plays an … Somatic mutations of Flt3 consisting
of internal tandem duplications (… in Flt3-ligand (FL)–independent kinase activation of Flt3. …

… receptor-type tyrosine kinases (RTKs),8,9 which play central … appearing FLT3 duplication,
we presume the duplications were … tandem duplications of the JM/TK1 domains of the FLT3 …

… some AML patients, the internal tandem duplication of the FLT3 is a member of the receptor
tyrosine kinase (… In this study, in and TK2) spaced by a kinase insert (KI) domain, and a C- …

… In addition, substitution mutations in the FLT3 kinase domain at Asp835 have recently been
… Internal tandem duplication of the JM domain of the FLT3 was detected in 41 out of 156 …