Gene co-expression analysis for functional classification and gene–disease predictions

S Van Dam, U Vosa, A van der Graaf… - Briefings in …, 2018 - academic.oup.com
… Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

[HTML][HTML] Classification and prediction of brain disorders using functional connectivity: promising but challenging

Y Du, Z Fu, VD Calhoun - Frontiers in neuroscience, 2018 - frontiersin.org
… In the following, we will review some commonly used feature selection and classification (or
prediction) strategies in fMRI functional connectivity based brain disorder studies. Several …

Computational approaches to disease‐gene prediction: rationale, classification and successes

RM Piro, F Di Cunto - The FEBS journal, 2012 - Wiley Online Library
… Indeed, text-mining of such biomedical literature was among the first approaches to
disease-gene prediction. This type of information, jointly with the functional information that we shall …

Disease prediction based on functional connectomes using a scalable and spatially-informed support vector machine

T Watanabe, D Kessler, C Scott, M Angstadt, C Sripada - Neuroimage, 2014 - Elsevier
… To the best of our knowledge, this is the first application of structured sparse methods in
the context of disease prediction using functional connectomes. Additional discussions of …

Functional annotations improve the predictive score of human disease‐related mutations in proteins

R Calabrese, E Capriotti, P Fariselli… - Human …, 2009 - Wiley Online Library
… In this article we describe a tool for predicting whether human SNPs are or are not disease-…
ways, and our defined functional GO score. The efficiency of the prediction is quite high as …

The effect of adding functional classification to ASA status for predicting 30-day mortality

O Visnjevac, S Davari-Farid, J Lee… - Anesthesia & …, 2015 - journals.lww.com
… the definition of the ASA PS classification. Thus, we hypothesize that incorporating function
capacity into the traditional ASA classification will better predict perioperative risk for both 30-…

PredictSNP: robust and accurate consensus classifier for prediction of disease-related mutations

J Bendl, J Stourac, O Salanda, A Pavelka… - PLoS computational …, 2014 - journals.plos.org
… In this study, we performed an evaluation of eight tools for prediction of the effects of mutations
on protein function and combined six of them into the consensus classifier PredictSNP (for …

Prediction of human protein function according to Gene Ontology categories

LJ Jensen, R Gupta, HH Staerfeldt, S Brunak - Bioinformatics, 2003 - academic.oup.com
… A robust estimate of the performance of a feature for a particular functional class was
calculated as the median test set Pearson correlation coefficient of the five neural networks in the …

Better prediction of functional effects for sequence variants

M Hecht, Y Bromberg, B Rost - BMC genomics, 2015 - Springer
… the effect class we may be over-estimating functional changes… to disease provide much
stronger evidence for functional … , disease variants are clearly strongly enriched in functional

Human disease genes: patterns and predictions

NGC Smith, A Eyre-Walker - Gene, 2003 - Elsevier
… help to predict human disease genes. We also investigated other factors affecting the mode
of evolution in the disease genes: Ka/Ks is significantly affected by protein function, mode of …