… Alcohol dependence (AD) is an important contributory … genetic factors, and the disorder has
a heritability of around 50%. The aim of the present study was to identify susceptibility genes …

… that genetic variation in the GABR gene cluster on chromosome 5q33 confers vulnerability
to alcohol dependence. … by chronic alcohol exposure play a role in alcohol-induced motor …

… These genes cluster on the chromosome 4q region on which several whole-genome studies
suggested linkage with the risk for alcohol dependence. Class I ADH, encoded by ADH1A, …

… alcoholism and certain receptor subunit genes. In this study, five published single nucleotide
polymorphisms in the GABR gene cluster… T1519C 1 in the GABRA6 gene, A15G 3 in the last …

… A gene cluster fine structure and (B) haplotype-based localization of alcohol dependence to
the 5q34 GABA A gene cluster… for the putative alcohol-dependence susceptibility locus. Cen …

… Formal genetic studies of alcohol dependence have shown that genetic factors play as large
a role … This genomic region harbors the alcohol dehydrogenase (ADH) gene cluster, which …

… Both groups reported data consistent with loci influencing risk for AD mapping in the vicinity
of an alcohol dehydrogenase (ADH) gene cluster on chromosome 4q (see below). Several …

… between the chromosome 15 GABAA receptor gene cluster and alcohol dependence. This
cluster has not been studied as extensively as the clusters on chromosome 4 (Edenberg et al.…

… alcohol dehydrogenase gene cluster on chromosome 4 in the genetic risk for alcohol
dependence … linkage-based studies of genetic influences on alcohol dependence. Finally, we …

… receptor complex in alcohol dependence syndrome has been … alcohol dependence
syndrome, we identified polymorphisms in the GABAA 2 and GABAA 6 receptor subunit genes on …