AAV hybrid serotypes: improved vectors for gene delivery

VW Choi, DM McCarty, RJ Samulski - Current gene therapy, 2005 - ingentaconnect.com
… strategies for generating hybrid serotypes with capsid protein … these AAV hybrid serotypes
for gene therapy as well as AAV … Important intricacies of using these hybrid serotypes will also …

AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials

N Hardcastle, NM Boulis, T Federici - Expert opinion on biological …, 2018 - Taylor & Francis
… Phase 1 clinical trials using AAV gene therapy for pediatric disorders – … of AAV gene delivery
to the spinal cord, particularly focusing on the most prominent AAV serotypes and delivery

The next step in gene delivery: molecular engineering of adeno-associated virus serotypes

J Wang, SM Faust, JE Rabinowitz - Journal of molecular and cellular …, 2011 - Elsevier
… Over one hundred AAV serotypes have been described with … structures of multiple AAV
serotypes have been solved (AAV2… AAV serotypes to the top of a list of promising gene delivery

[HTML][HTML] Cellular and tissue selectivity of AAV serotypes for gene delivery to chondrocytes and cartilage

DS Yoon, KM Lee, S Cho, EA Ko, J Kim… - … Journal of Medical …, 2021 - ncbi.nlm.nih.gov
… belonging to different serotypes. Potential differences between AAV serotypes may exist
in … We aimed to determine the most efficient AAV serotype for the gene therapy of intra-articular …

Comparison of AAV serotypes for gene delivery to dorsal root ganglion neurons

MRJ Mason, EME Ehlert, R Eggers, CW Pool… - Molecular Therapy, 2010 - cell.com
… Direct injection of DRG for gene delivery may be preferable for some … AAV serotypes using
this delivery method are not known. We have compared AAV vectors based on serotypes 1, 2, …

Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants

MJ Benskey, NC Kuhn, JJ Galligan, J Garcia, SE Boye… - Molecular Therapy, 2015 - cell.com
… of AAV in the ENS. The purpose of the current study was to examine the ability of various
AAV serotypes to infect cells of the ENS. Adult rats received direct injections of AAV expressing …

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates

PA Lawlor, RJ Bland, A Mouravlev, D Young… - Molecular therapy, 2009 - cell.com
… agent for somatic gene transfer into the central nervous system (CNS). To date, AAV-mediated
gene delivery to the CNS is based on serotypes 1–9, with efficient gene transfer to …

Recombinant AAV‐mediated gene delivery to the central nervous system

L Tenenbaum, A Chtarto, E Lehtonen… - The Journal of Gene …, 2004 - Wiley Online Library
… Alternative AAV serotypes having different requirements than AAV2 are likely to show
different cellular tropisms. For example, AAV5 using PDGFR is likely to harbor a different cellular …

[HTML][HTML] Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas

RH Kofoed, CL Dibia, K Noseworthy, K Xhima… - Journal of Controlled …, 2022 - Elsevier
… As demonstrated in the current study, natural AAV serotypes provide gene delivery within
the FUS spots in the brain with areas of transduction ranging from 0.01 mm 2 (AAV5, …

Adeno-associated virus serotypes: vector toolkit for human gene therapy

Z Wu, A Asokan, RJ Samulski - Molecular therapy, 2006 - cell.com
AAV vectors. The current review is focused on naturally occurring AAV serotypes and engineering
hybrid AAV … classification, and gene delivery applications of AAV serotypes have been …