… Variation in gene expression is an important mechanism underlying susceptibility to complex
disease. The simultaneous genome-wide assay of gene expression and genetic variation …

… of nearby genes (cis-eGenes). Using published GWAS datasets with 39,165 single-… with
1,960 traits, we explored whole blood gene expression associations of trait-associated SNPs in …

… We show that even if genetic effects on complex traits were entirely mediated by gene
expression, many GWAS hits would not be discovered as significant eQTLs (even in the correct …

… Nevertheless, given the extensive genetic complexity observed … of complex cellular and
physiological traits. Indeed, many macroscopic phenotypes may have a basis in gene expression…

… These results suggest that genetic variants that alter gene expression, rather than variants
that alter protein sequences, form the primary basis of natural variation in complex traits. This …

… genetic correlation between gene expression and a complex trait and utilize it to estimate the
genetic … into the role of gene expression in the susceptibility of complex traits and diseases. …

… genetic variation associated with > 60 human traits by … 36 complex traits and 1,246 DNAm
sites. We also use SMR to characterize the relationship between DNAm and gene expression …

… or intergenic sequence variation, gene expression level, and trait phenotype is less well …
of regulatory genetic variants that control the level or pattern of expression of many genes in …

… genes, appropriately accounts for linkage disequilibrium (LD), and jointly analyzes gene
expression … of cell-specific gene expression to prioritize trait-relevant genes. Finally, we provide …

… We profiled gene expression using Affymetrix oligonucleotide … gene expression and
pharmacological and behavioral traits … often generated by common quantitative trait loci. We found …