Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders

AR Hammerschlag, CA de Leeuw… - Psychological …, 2020 - cambridge.org
… We identified 19 gene sets that were significantly associated with the five psychiatric disorders
combined, of which we excluded five sets because their associations were likely driven by …

Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations

WR Reay, MJ Cairns - Translational psychiatry, 2020 - nature.com
… ) and eating disorder (ED). We sought to identify pleiotropic genes and gene-sets which were
… We uncovered several interesting schizophrenia-associated genes and gene-sets which …

Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders

MM Darby, RH Yolken, S Sabunciyan - Translational psychiatry, 2016 - nature.com
… in gene expression that accompany psychiatric disorders, we … gene sets containing a
disproportionate number of genes … For each disorder, we ranked all the genes using the Wald test …

Exploring the genetic overlap between twelve psychiatric disorders

C Romero, J Werme, PR Jansen, J Gelernter… - Nature …, 2022 - nature.com
gene set and gene property analysis. After correcting for 10,126 tests and 12 psychiatric
disorders (that is, 9,508 gene sets 45 , and gene … , correcting separately for gene sets, tissues or …

Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis

S Cheng, B Han, M Ding, Y Wen, M Ma… - Briefings in …, 2020 - academic.oup.com
… Using the randomly generated gene set annotation data, we reconducted GSEA of five
psychiatric disorders, obesity and T2D using the same analysis approach. As expected, no …

Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders

J Cabana-Domínguez, B Torrico, A Reif… - … psychiatry, 2022 - nature.com
… the wide DA gene set, for BIP with the wide SERT gene set, and for … genes associated
with some psychiatric disorders, twelve of them with two conditions, and also in the cross-disorder

Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders

KM Ersland, A Christoforou, C Stansberg, T Espeseth… - PloS one, 2012 - journals.plos.org
… In this analysis, we also included a gene set consisting of “housekeeping” genes as a …
signal for this gene set in any of the psychiatric disorder or non-psychiatric phenotype GWASs …

Biological pathways and networks implicated in psychiatric disorders

PF Sullivan, D Posthuma - Current opinion in behavioral sciences, 2015 - Elsevier
… We review 42 studies that tested biological pathways in five major psychiatric disorders. …
pathways, highlighting the critical need for robust approaches to gene-set/pathway analysis. …

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

Cross-Disorder Group of the Psychiatric Genomics … - The Lancet, 2013 - Elsevier
… significant enrichment for a set of calcium channel activity genes associated with catalysis of
… 10 −3 , 20 of 67 gene regions in this set were associated in the five-disorder meta-analysis, …

Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder

J Guan, JJ Cai, G Ji, PC Sham - Translational psychiatry, 2019 - nature.com
gene expression analysis method, coupled with consensus co-expression network analysis,
to identify gene sets … We identify eight gene sets with dysregulated expression shared by …