… However, the diagnostic yield remains less than 50% even after extensive workups (5), with
the costs of clinical and molecular genetic analysis for patients whose diagnosis is not clear …

… Mice are the model of choice for mammalian genetic analysis ( … In themselves, map positions
are important because they suggest candidate genes already mapped to the disease gene …

… the quantitative genetic analysis of gene-expression profiles, referred to as genetical
genomics [69] or expression QTL (eQTL) mapping [70]. Treating genome-wide gene-expression …

… Although the large number of tests limits the statistical power to detect SGE on individual
genes (12,898 genes tested), we identified three genes with significant effects (Srsf2, Phlpp2, …

… This review also discusses the potential of comprehensive genetic analyses to decipher the
relationship between perio- dontal disease and environmental factors. Table 1 summarizes …

… The understanding of host genetic variation in disease … for a genetic interpretation of field
disease data, for diseases caused … introduce epidemiological concepts to quantitative genetics. …

… disease risk estimates will only translate into health benefits if acting on them modifies disease
outcomes, and if those informed of these genetic … nicating DNA based disease risks are …

… in family studies to identify disease and susceptibility genes. These studies, which arc … , rely
on the usc of genetic analysis methods such as linkage and segregation analyses. A notable …

… result in autoimmune disease. Both genetic regulation of immune cell levels and their
relationships with autoimmunity are largely undetermined. Here, we report genetic contributions to …

… We describe one of the first analyses of large CNVs segregating at rare frequencies (0.1%–1…
information in a disease study, and implications of our results for future genetic analyses. …