… ) has enabled the chromosome localization of almost 40 genes that predispose to
autoimmunity in animal models and in human disease (Figure 1). Human studies are in their …

… identify susceptibility genes in a number of autoimmune diseases. 2. … Autoimmune diseases
also seem to cluster within families. This has been confirmed by the 5th Genetic Analysis …

… genetics of AID, but we will mainly focus on the recent genetic associations of autoimmunity
with common genetic … SNPs typing is a powerful tool for genetic analysis, and is particularly …

… ITGAM has also been the focus of extensive candidate gene analyses, driven by the results
of previous linkage studies (150). Thus, like STAT4 and CARD15, this demonstrates that …

… Modern tools for genetic analysis … analysis of similarities and differences among several
AID. Using this class of approaches the unique genetic landscape for each autoimmune disease …

… Our understanding of which genes predispose to different autoimmune diseases has … of
most autoimmune diseases can be explained and nearly half of this identified genetic risk is due …

… analysis and causal-gene discovery and highlight some exceptional recent advances, from
the perspective of a classic autoimmune disease… For example, in the latest genetic analysis of …

… Genetic analysis of these families reveals that PTPN22 is associated with several different …
with expertise in the genetics of a wide range of autoimmune diseases were asked to serve as …

… genetic roots to these diseases. Two approaches have been undertaken to sustain the “…
genetic origin” theory of ADs. Firstly, a clinical genetic analysis showed that autoimmunity …

… genetic diversity is the result of population genetic forces. This genetic variation influences
disease … Autoimmune diseases (ADs) are a family of complex heterogeneous disorders with …