Genetic architecture of complex traits in plants

JB Holland - Current opinion in plant biology, 2007 - Elsevier
… have begun to study complex trait genetics in large populations. Recent analyses of very
large maize populations revealed a substantially more complex genetic architecture than was …

A global overview of pleiotropy and genetic architecture in complex traits

K Watanabe, S Stringer, O Frei, M Umićević Mirkov… - … genetics, 2019 - nature.com
… our understanding of the genetic architecture of traits. Occasionally, … genetic architecture
varies across multiple complex traits, we assessed h 2 SNP and the polygenicity of 558 traits

Mapping the genetic architecture of complex traits in experimental populations

J Yang, J Zhu, RW Williams - Bioinformatics, 2007 - academic.oup.com
… whole genetic architecture into account and might contribute to biased estimation of genetic
… is proposed for modeling the genetic architecture of complex trait, which integrates the …

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

H Shao, LC Burrage, DS Sinasac… - Proceedings of the …, 2008 - National Acad Sciences
… Although the individual genes shed important light on … genetic architecture of complex
traits, including the total number of genes, the typical effect sizes for risk alleles, and the genetic

Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture

ME Goddard, KE Kemper… - … of the Royal …, 2016 - royalsocietypublishing.org
… the genetic architecture of complex traits. The genetic architecture of complex traits is even
more complex than previously thought: in almost every trait studied there are thousands of …

Functional mapping—how to map and study the genetic architecture of dynamic complex traits

R Wu, M Lin - Nature Reviews Genetics, 2006 - nature.com
… the mathematical aspects of dynamic traits into the QTL mapping theory. Here we present
the conceptual model for functional mapping of complex traits and provide guidelines for the …

Genetic architecture of quantitative traits and complex diseases

W Fu, TD O'Connor, JM Akey - Current opinion in genetics & development, 2013 - Elsevier
… the genetic architecture of quantitative traits and complex … insights into the genetic architecture
of phenotypic diversity … of the genetic architecture of quantitative and complex traits will …

The genetic architecture of quantitative traits

TFC Mackay - Annual review of genetics, 2001 - annualreviews.org
trait loci (QTL) with effects that aresensitive to the genetic, … complex traits; and to determine
their gene frequencies and … individual genes underlyingvariation in complex traits (200). …

Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies

A Eyre-Walker - Proceedings of the National Academy of …, 2010 - National Acad Sciences
… the mutations and genes involved in complex traits, particularly those involved in human
disease, both to aid in predicting risk and to further understand the genetic basis of disease. …

Genetic architecture: the shape of the genetic contribution to human traits and disease

NJ Timpson, CMT Greenwood, N Soranzo… - … Reviews Genetics, 2018 - nature.com
complex traits, a multi pronged analysis is likely to be needed to elucidate genetic architecture
… we describe an approach to partially resolve the architecture of a polygenic, complex trait. …