… To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …

… IBD subtypes, ulcerative colitis (UC) and Crohn’s disease (CD), … genetic architecture between
MS and IBD overall and UC and CD independently. We find a significantly greater genetic …

… Comparative genetic architecture across ancestries We first compared the IBD genetic
architecture for common variants across the following three EAS samples: Chinese (SHA1), …

… Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

… disorders represented by common alleles. Here we aimed to define the genetic architecture
of … A total of 1495 patients were recruited, including 761 patients with Crohn’s disease (CD; …

… study of inflammatory bowel disease encompassing 1,774 … Although no new loci for
inflammatory bowel disease are … an elevated odds ratio for Crohn disease in African Americans. A …

… twin studies as leading to generalized insight into the genetic architectures of complex traits.
If we, … the genetic architecture of inflammatory bowel disease. Nature 2012; 491: 119–124. …

… , suggesting that the genetic architecture of disease severity may be distinct from the …
disease severity and on the main research venues to decipher the genetic architecture of disease …

… Our findings indicate possible shared genetic architecture and pathways between ALS
and IBD. These results provide insights into the pathogenesis and therapeutics of IBD and …

… transformative approaches in human genetics and functional genomics. Here we describe
IBD as a model disease in the context of leveraging human genetics to dissect interactions in …