… and across ancestries using 17 quantitative phenotypes Genetic architecture of 17 studied
phenotypes To understand how trait genetic architecture influences the accuracy of PRSs …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we …

… genetic architectures. … Genetic prediction of complex traits requires the development of
statistical methods that can properly model polygenic architecture and construct a polygenic score …

… We have learned an enormous amount about the genetic architecture of complex traits
through GWASs but interpreting this knowledge in the context of biological processes has been …

… polygenic phenotypes. We review how these tools have informed the current knowledge on
the genetic architecture … these tools may improve genetic prediction and estimate discovery …

… genetic architecture of complex traits. Accurate estimates of genome-wide polygenicity can
be used to improve the prediction accuracy of polygenic … context of phenotype prediction [7–…

… and type of selective sweeps and the demography are added as parameters to the modern
genetic architecture, we can predict the evolutionary rate, σ m , and V S with 70% accuracy. …

… with a wide range of genetic architectures, cross-population genetic overlaps and discovery
GWAS sample sizes in simulations, and improves the prediction of quantitative traits and …

… The genetic architecture of neuroanatomical diversity could result, alternatively, from the …
genome-wide polygenic scores (GPSs), which provide a phenotypic prediction at the individual …

… polygenic only models for gene expression prediction across populations. Thus, the genetic
architecture of gene expression for many genes … genes do perform better in more polygenic …