… Type 1 diabetes mellitus (T1D) is a complex autoimmune disorder characterised by loss of
the insulin-producing pancreatic beta cells in genetically predisposed individuals, ultimately …

… well as shared genes, including in utero environment, plus variability in genetic structure even
… However, the genetics of autoimmune diabetes shows substantial disease heterogeneity, …

… of patients with long-duration Type 1 diabetes are insulin microsecretors” [2]. Although we
did not use a mixed meal to stimulate C-peptide secretion, plasma glucose measured on the …

… Type 1 diabetes (T1D) patients with low genetic risk scores (GRS) may be … genetic loci.
The T1D-GRS2 provides us an opportunity to look into the genetic architecture of these patients. …

… genome-wide association study (GWAS) and sequencing studies, and to discuss the latest
loci added to the growing repertoire of genetic signals predisposing to type 1 diabetes (T1D). …

… have been implicated in both monogenic and polygenic diabetes (8). A recent simulation
study evaluated genetic architectures for consistency with results from T2D genetic studies and …

… Here, we describe the types of genetic architecture that have been observed, how architecture
can be measured … Type 1 diabetes mellitus is associated with common and low-frequency …

… Diabetes Association classifies diabetes into four categories. The first two categories are type
1 diabetes (T1D) and type 2 diabetes (… a complex interaction of genetic and environmental/…

… Most genetic variants associated with T2D are common variants with … genetic component
of T2D can be explained by common variants relies upon the shape of the genetic architecture …

… experienced throughout thelifespan (1). This complex genetic architecture has important
consequences for understanding the pathophysiology of type 2 diabetes, both for researchers …