… in MTHFR, the gene encoding methylene tetrahydrofolate reductase. … associationstudies, because proper evaluation of these associations is critical both to understanding the genetics …
CM Lewis, J Knight - Cold Spring Harbor Protocols, 2012 - cshprotocols.cshlp.org
… geneticassociationstudies, but it focuses specifically on case–control studies in candidate genes … Even in this era of genome-wide studies, case–control studies still form the majority of …
… for resolving discrepancies in geneticassociationstudies. Persistent difficulties in … in genetic associationstudies are almost certainly because genetic effects are small, requiring studies …
… to the assessment of association between genetic variants and … tests in genome-wide associationstudies. We discuss the … robust conclusions from future geneticassociationstudies. …
… genetic polymorphisms at once, geneticassociationstudies … geneticassociationstudies; it then discusses the primary features differentiating genetic from standard associationstudies …
We investigated selection and analysis of tag SNPs for genome-wide associationstudies by specifically examining the relationship between investment in genotyping and statistical …
YH Lee - Annals of laboratory medicine, 2015 - ncbi.nlm.nih.gov
… of geneticassociationstudies is … Geneticassociationstudies of candidate genes have shown that the majority of initial positive associations cannot be reproduced in subsequent studies …
… by meta-analysis 370 studies addressing 36 geneticassociations for various … genetic associationstudies require cautious replication—an issue for both linkage and associationstudies…
H Campbell, I Rudan - The pharmacogenomics journal, 2002 - nature.com
The potential of the geneticassociation approach for the identification of genetic variants that alter susceptibility to common complex disease is well recognised. 1 This potential equally …