A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

BB Lake, S Chen, M Hoshi, N Plongthongkum… - Nature …, 2019 - nature.com
… Here we develop a robust tissue processing and single-… establish a molecular “blueprint” of
adult human kidney tissue. Our … heterogeneity and insights into kidney organization, function …

Regulation of Brain Development

N Herschkowitz - Investigation of Brain Function, 1981 - Springer
… The brain structures are formed according to a genetic blueprint, according to which enzymatic
activities are turned on at determined times and, if substrates are available, complex and …

The aquaporins, blueprints for cellular plumbing systems

P Agre, M Bonhivers, MJ Borgnia - Journal of Biological Chemistry, 1998 - ASBMB
… The variability is particularly evident in mammalian kidney where proximal tubules and …
the kidney fails to respond to vasopressin, and mutations have been identified in the gene

Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors

S Zeng, Q Qing, W Xu, S Yu, M Zheng, H Tan… - Frontiers in …, 2024 - frontiersin.org
genetic blueprint and clinical history, represents a dynamic paradigm in healthcare evolution.
The emerging field of personalized anesthesia is at the intersection of genetics … and kidney

Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease

YC Tsai, MC Kuo, JC Huang, WA Chang, LY Wu… - Cell Death & …, 2023 - nature.com
… C Blueprint of the scRNA-sequence of the kidney. D Cell clusters of the kidney of db/m mice
… In this study, we found that db/db mice lost interaction related to kidney development, and …

Stepwise developmental mimicry generates proximal-biased kidney organoids

J Schnell, Z Miao, MA Achieng, CC Fausto, V Wang… - bioRxiv, 2024 - biorxiv.org
… stem cell-derived kidney organoids are used for modeling renal development, disease, and
… the development of proximal tubule precursors in kidney organoids by following a blueprint

[PDF][PDF] Importance of nutrigenomics and nutrigenetics in food science

TG Uthpala, HN Fernando, A Thibbotuwawa… - 2020 - dr.lib.sjp.ac.lk
… to food based on their genetic makeup. Even though humans are similar in genetics, we
all have slight differences in our genetic blueprints due to single nucleotide polymorphisms (…

Programmable DNA binding oligomers for control of transcription

PB Dervan, RM Doss… - … Medicinal Chemistry-Anti …, 2005 - ingentaconnect.com
… Abstract: Mapping and sequencing the genetic blueprint in human, mice… gene inhibition
involved the selective inhibition of RNA pol III transcription of a 5S RNA gene in Xenopus kidney

Protein kinase A downregulation delays the development and progression of polycystic kidney disease

X Wang, L Jiang, K Thao, CR Sussman… - Journal of the …, 2022 - journals.lww.com
… thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory subunit
RIα is increased in kidneys of orthologous mouse models. Kidney-specific knockout of RIα …

The Y chromosome: a blueprint for men's health?

AA Maan, J Eales, A Akbarov, J Rowland… - … of Human Genetics, 2017 - nature.com
… Experimental delivery of SRY3 to normotensive rat kidneys raises blood pressure, 30, 31 a
… RAAS gene expression, although in vivo SOX3 is primarily transcribed in non-kidney tissues. …