… The first and so far the best-developed is the search for the biochemical genetic basis of …
Collectively, they tell us much about the genetics of health span. Given that the major risk factor …

… in older ages, studies that identify causal mechanisms from modifiable risk factors to healthspan
are needed. Genetic predispositions are not affected by environmental factors or reverse…

… such as low-circulating insulin-like growth factor 1 (IGF-1) and … SNPs) to unlock the genetic
determinants of exceptional longevity … of drugs that may delay aging and prolong health span. …

… genetic factors may contribute to health span collectively, we assess the joint effects of genetic
… interaction effect of testosterone and genetic propensity on health span, we still find the …

… span without also extending the duration of healthy time is not a goal of aging research. But
how do we define health span … that one can use to define health span in a laboratory setting? …

… , life span is now recognized as a complex trait and genetic … beyond classical Mendelian
genetics to polygenic inheritance … to achieve: extension of health span and not merely life span. …

… Both life span and health span are influenced by genetic, environmental and lifestyle factors…
changes could interfere with the genetic profile to deeply affect health span and, in some …

… Understanding the molecular (including genetic) basis of health span and life span may
help us find optimal targets for intervention, whether it be common risk factor modification, such …

… Since gene variant contributions to health-span and life-span are usually small, we
obtained the corresponding effect size and test statistics with the help of a simple perturbative …

… This review was intended to summarize our current understanding of genetic factors affecting
the … genes appears to affect both telomere length, and life span and health span in humans. …