… In this review of candidate gene association studies, nearly one-third of gene-variant cancer
associations were statistically significant, with variants in genes encoding for metabolizing …

… We find that a candidate gene approach tends to have greater statistical power than
studies that use large numbers of single nucleotide polymorphisms (SNPs) in genome-wide …

… However, the genes were chosen based on the experience … candidate genes. In addition,
the sample size was relatively small for a tag-SNP study, but we limited the number of genes …

… relation of 112 polymorphisms in 71 candidate genes to the … that the C1019T polymorphism
in the connexin 37 gene was … polymorphism in the plasminogen-activator inhibitor type 1 …

… The quandary becomes particularly acute when we are trying to determine if a missense
alteration in a candidate gene is important (disease associated). How many control samples …

… genes in the development of renal scarring after UTIs. This review also shows that only few
possible candidate genes … the hypothesis that some gene polymorphisms may exert their …

… Our primary goal in this study was to identify variations, in candidate genes, contributing to
vulnerability to heroin addiction. Our top signals are from genes encoding opioid receptors, a …

Background Like other complex diseases including drug addiction, genetic factors can interfere
with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were …

… Although genetic linkage analyses4 – 8 and association studies9 – 15 have implicated …
and candidate genes in predisposition to MI, the genes that contribute to genetic susceptibility to …

… Remarkably, it is within this tiny fraction of a genome, namely the collection of sequence
variations, that we find an opportunity to decipher genetic determinants of disease susceptibility …