Genetic association studies in rheumatic heart disease (RHD) have the potential to
contribute toward our understanding of the pathogenetic mechanism, and may shed light on …

… of the recently described genes that underlie these conditions … disease susceptibility genes
in these diseases and progress in establishing the molecular basis by which genetic variation …

… the genetic component. A decade ago, most reviews on the genetics of rheumatic diseases
… In a recent report genetic variation within PAD14 appears not to be a major risk factor for RA …

… This review discusses how integration of data can help characterize and prioritize genetic
variants … of the mechanisms of human rheumatic diseases. Heritability of rheumatic diseases …

… Today, these methodologies have revolutionized disease-gene discovery and are now
being applied to genetics studies of rheumatic disease. While candidate gene and genome-wide …

… –gene and gene–environment interactions. The genetic studies conducted to date have
chiefly investigated simple genetic variants (insertion-deletion, single-nucleotide polymorphisms)…

… of gene variants that influence genetically complex diseases and focuses on what we have
learned about the rheumatic diseases … Our review of the disease-associated loci identified to …

… -focused GWAS uses a case–control study approach to compare the frequency of genetic
variants in patients with a disease to controls without the disease (Table 1). As in all …

… responsible for rheumatic diseases. The sector of human genetics which uses the genetic
variation found associated with genes has two basic approaches to link variation with complex …

… states in delineating causal genetic variants is discussed, highlighting … other rheumatic
diseases is that genetic associations influence disease phenotype and not only generic disease …