Beyond safety: mapping the ethical debate on heritable genome editing interventions

M Almeida, R Ranisch - Humanities and Social Sciences …, 2022 - nature.com
… or heritable genome editing interventions) greatly … of genome editing and their impact on
the debate of the permissibility or otherwise of human heritable genome editing interventions in …

Reproductive genome editing interventions are therapeutic, sometimes

C Palacios‐González - Bioethics, 2021 - Wiley Online Library
genome editing interventions can be therapeutic in nature, and thus that it is false that all such
interventions … are met by certain reproductive genome editing interventions. I then defend …

Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions?

R Ranisch - Bioethics, 2020 - Wiley Online Library
… of new tools for gene editing such as CRISPR/Cas9. Recently, germline genome editing (GGE) …
Since then, a handful of studies have reported experiments with gene editing techniques …

Gene editing of stem cells for kidney disease modelling and therapeutic intervention

RWK Lau, B Wang, SD Ricardo - Nephrology, 2018 - Wiley Online Library
… is to produce a genome editing tool with high editing specificity, high editing efficiency and
minimal off-target creation of by-projects, which is not within the gene of interest.30 NHEJ, …

Reassess the law and ethics of heritable genome editing interventions: Lessons for China and the world

Q Bu - Issues L. & Med., 2019 - HeinOnline
… Heritable genome editing interventions should only be permitted provided that legitimate …
of health economics arising from heritable genome editing interventions for health services."" …

Genomic interventions for sustainable agriculture

A Bohra, U Chand Jha, ID Godwin… - Plant Biotechnology …, 2020 - Wiley Online Library
… sequencing and explain how the presence of these genome resources in combination
with gene editing techniques has revolutionized the procedures of trait discovery and …

Is enhancement the price of prevention in human gene editing?

ET Juengst, GE Henderson, RL Walker… - The CRISPR …, 2018 - liebertpub.com
… The stated goal of this research is to develop somatic human geneediting interventions to
prevent age-associated degenerative neurological conditions such as Alzheimer's disease by …

Gene editing and germ-line intervention: the need for novel responses to novel technologies

C Addison, S Taylor-Alexander - Molecular Therapy, 2015 - cell.com
… We contend that the response of the scientific community to the debate on gene editing could
… They also present an opportunity for dialogue that can enhance the impact of gene editing

Heritable Genome Editing in a Global Context: National and International Policy Challenges

A Rosemann, A Balen, B Nerlich… - Hastings Center …, 2019 - Wiley Online Library
… However, a challenge for the development of international guidelines is that the technical
procedures and effects of clinical heritable genome editing interventions are different for each …

Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic

R Ranisch, K Trettenbach, G Arnason - Medicine, Health Care and …, 2023 - Springer
… on research ethics issues in germline genome editing by exploring key issues … genome
editing into clinical practice, we outline the specific challenges associated with such interventions