Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

J Jüttner, A Szabo, B Gross-Scherf, RK Morikawa… - Nature …, 2019 - nature.com
… We show that a number of these AAVs specifically target expression to neuronal and glial
cell types in the mouse and non-human primate retina in vivo and in the human retina in vitro. …

The cellular composition and glia–neuron ratio in the spinal cord of a human and a nonhuman primate: comparison with other species and brain regions

J Bahney, CS von Bartheld - The Anatomical Record, 2018 - Wiley Online Library
… We show that glial cells make up a larger fraction of total cells in the primate spinal cord (higher
GNR) than glial cells in the primate cerebral cortex, and we show that the GNR in the …

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates

PA Lawlor, RJ Bland, A Mouravlev, D Young… - Molecular therapy, 2009 - cell.com
glial cells have not been observed. Recently, additional endogenous AAVs have been isolated
from nonhuman primate … with AAV8, another nonhuman primate isolate previously shown …

[HTML][HTML] Translational utility of the nonhuman primate model

AF Tarantal, DJ Hartigan-O'Connor… - Biological Psychiatry …, 2022 - Elsevier
Nonhuman primates are essential for the study of human … unique features of the nonhuman
primate model system, specifically … , which slows production of cortical neurons and glia (78). …

Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates

DM Gash, GA Gerhardt, BJ Hoffer - Advances in pharmacology, 1997 - Elsevier
Glial cell line-derived … of cell types throughout the body, our studies have focused on
analyzing its effects on the nigrostriatal dopaminergic system in rodents and nonhuman primates. …

Contributions of non-human primates to neuroscience research

JP Capitanio, ME Emborg - The Lancet, 2008 - thelancet.com
… Although non-human primates have contributed to many areas of biomedical research, we
… , the role of non-human primates in development of new treatments (eg, stem cells, gene …

Neurogenesis in primates versus rodents and the value of non-human primate models

R Zhang, H Quan, Y Wang, F Luo - National Science Review, 2023 - academic.oup.com
… in the VZ undergo distinct morphological, molecular, and mitotic changes, gradually
transforming into apical RG cells (aRG cells or ventricular radial glia cells, vRG cells) [3]. aRG …

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

SJ Gray, V Matagne, L Bachaboina, S Yadav… - Molecular Therapy, 2011 - cell.com
Other labs have previously reported the ability of adeno-associated virus serotype 9 (AAV9)
to cross the blood-brain barrier (BBB). In this report, we carefully characterized variables that …

Cell locations for AQP1, AQP4 and 9 in the non-human primate brain

II Arciénega, JF Brunet, J Bloch, J Badaut - Neuroscience, 2010 - Elsevier
… located in the white matter and the glia limitans, possibly involved in water … primate brains.
This report describes a detailed study of AQP1, 4 and 9 distributions in the non-human primate

Varicosities of intraretinal ganglion cell axons in human and nonhuman primates

L Wang, J Dong, G Cull, B Fortune… - … ophthalmology & visual …, 2003 - iovs.arvojournals.org
… In transverse-cut axons in one of the nonhuman primate retinas, … glial cells or the other
axons (Fig. 7) . Similar junctions were also found between pairs of neighboring glial cells. …