… Upon cellular entry, GCs bind to either the Type I mineralocorticoid receptor (MR), or the
Type II glucocorticoid receptor (GR). MR has a much higher affinity (0.5 nM) for GCs than does …

… receptors, for example, glucocorticoid receptor (GR), mineralocorticoid receptor (MR) or
estrogen receptor (ER), is … Indeed, microglia express these ligand-dependent nuclear receptors. …

… system (CNS). As a consequence, GCs are also used in the treatment of CNS inflammation.
… Glucocorticoid receptor binding site in the HIV long terminal repeat. J Virol 66: 586–590. …

… different levels in the inflammation pathway to suppress ongoing inflammation, including via
… identified in the hippocampal microglia and possibly other CNS macrophages. Acute (97, 98…

… pro-inflammatory GC actions, they are both likely to be mediated by the same corticosteroid
receptor… The hippocampus contains both high-affinity mineralocorticoid receptors, which are …

… resistance resulting from impairments in local factors affecting glucocorticoid availability
and function, including the glucocorticoid receptor (GR). The enhanced inflammation and …

… can act as pro-inflammatory agents depending on the dose, … of glucocorticoids pro-inflammatory
gene regulation in the brain. … Glucocorticoid receptor isoforms are subject to various …

… Distinct molecular mechanisms of the glucocorticoid receptor (GR) contribute to different
anti-inflammatory effects. Recently inflammatory models have been investigated using …

… stress hormones (GCs) are well known for being anti-inflammatory, … inflammation during
acute brain injury. Because the GC receptor (GR) is ubiquitously expressed throughout the brain…

… Glucocorticoids (GCs) are widely used to treat inflammatory … the GC receptor, a member of
the nuclear receptor superfamily that … inflammatory autoimmune disease of the central nervous …