The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases

M Braun, JJ Iliff - International review of neurobiology, 2020 - Elsevier
… waste products in the brain. However, this ignores the likely role of accumulating peripheral
metabolic waste products in the blood in promoting this glymphatic dysfunction. Increased …

[HTML][HTML] Interaction between blood-brain barrier and glymphatic system in solute clearance

ICM Verheggen, MPJ Van Boxtel, FRJ Verhey… - Neuroscience & …, 2018 - Elsevier
… is also largely dependent on the glymphatic system (Kress et al., 2014; Iliff et al., 2012).
The connections between BBB disruption, glymphatic dysfunction and Aβ accumulation could …

The glymphatic pathway in neurological disorders

MK Rasmussen, H Mestre, M Nedergaard - The Lancet Neurology, 2018 - thelancet.com
Glymphatic dysfunction, probably related to perturbed AQP4 expression, has been shown in
brain injury, Alzheimer's disease, and stroke. The recent characterisations of the glymphatic

Yi-Zhi-Fang-Dai formula exerts neuroprotective effects against pyroptosis and bloodbrain barrier–glymphatic dysfunctions to prevent amyloid-beta acute …

Z Lyu, Q Li, Z Yu, Y Chan, L Fu, Y Li… - Frontiers in …, 2021 - frontiersin.org
… Background: The dysfunctional bloodbrain barrier (BBB)–glymphatic system is responsible
… causing BBB–glymphatic dysfunctions and Aβ acute accumulation in the brain. Targeting …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
… In summary, the available (murine) literature examining post-TBI glymphatic system
dysfunction consistently shows decreased flow through the GVS, loss of AQP4 polarization on …

The bidirectional link between sleep disturbances and traumatic brain injury symptoms: A role for glymphatic dysfunction?

JA Piantino, JJ Iliff, MM Lim - Biological psychiatry, 2022 - Elsevier
… the role of glymphatic dysfunction as a … glymphatic dysfunction and sleep disruption caused
by mTBI may have an additive effect on waste clearance, leading to cerebral dysfunction and …

Neurovascular-glymphatic dysfunction and white matter lesions

B Sabayan, RGJ Westendorp - Geroscience, 2021 - Springer
… consequence of glymphatic dysfunction. Intriguingly, … glymphatic dysfunction [36]. In addition,
experimental studies have shown that dysfunction in certain components of the glymphatic

A clinical primer for the glymphatic system

LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
… The so-called glia-lymphatic or glymphatic system is thought … The glymphatic clearance
system then facilitates flow into more … Glymphatic dysfunction has been implicated in the …

Glymphatic dysfunction: a bridge between sleep disturbance and mood disorders

T Yan, Y Qiu, X Yu, L Yang - Frontiers in Psychiatry, 2021 - frontiersin.org
… Both animal and human studies have reported suppressed glymphatic transport, abnormal
… , the “glymphatic dysfunction” hypothesis which suggests that the dysfunctional glymphatic

Disturbance of intracerebral fluid clearance and bloodbrain barrier in vascular cognitive impairment

M Ueno, Y Chiba, R Murakami, K Matsumoto… - International journal of …, 2019 - mdpi.com
… the contribution of the glymphatic system to tau pathology. Some studies reported the effects
of glymphatic system failure on the brain function. Dysfunction of the glymphatic system and …