H2S Donors and Their Use in Medicinal Chemistry

E Magli, E Perissutti, V Santagada, G Caliendo… - Biomolecules, 2021 - mdpi.com
Hydrogen sulfide (H 2 S) is a ubiquitous gaseous signaling molecule that has an important …
This review has been designed in order to summarize the currently available H 2 S donors; …

Medicinal Chemistry: Insights into the Development of Novel H2S Donors

Y Zhao, A Pacheco, M Xian - … and pharmacology of hydrogen sulfide, 2015 - Springer
… H 2 S-releasing capabilities of the donors are quite different, therefore leading to very … H
2 S donors is crucial. Herein, we provide a review on currently available H 2 S donors. H 2 S-…

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

A Martelli, L Testai, V Citi, A Marino… - … medicinal chemistry …, 2013 - ACS Publications
… Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes
cutaneous wound healing. Acta Materia Medica 2022, 1 (4) https://doi.org/10.15212/AMM-2022-…

Therapeutic application of hydrogen sulfide donors: the potential and challenges

D Wu, Q Hu, Y Zhu - Frontiers of medicine, 2016 - Springer
… In this review, we summarize the chemistry and biomedical applications of H2S-releasing …
potential and challenges of H2S donors in therapeutic use. H2S production and metabolism …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
… for the design of H 2 S donors. The donor 12 was synthesized through a click chemistry-like
reaction, indicating the assembly of the donor 12 into macromolecular systems is feasible. …

Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

A Corvino, F Frecentese, E Magli, E Perissutti… - Antioxidants, 2021 - mdpi.com
… In fact, much evidence has suggested that hydrogen sulfide … role of H 2 S donors in different
disease models has been … of currently available H 2 S donors, classifying them by the H 2 S-…

The role of hydrogen sulfide and H2S-donors in myocardial protection against ischemia/reperfusion injury

V Citi, E Piragine, L Testai, MC Breschi… - … medicinal chemistry, 2018 - ingentaconnect.com
H2S against I/R myocardial injuries, led to investigate several molecules able to release H2S
(H2Sdonors)… Besides NaHS, which was considered a too fast H2Sdonor to be employed in …

Hydrogen sulfide (H 2 S) releasing agents: chemistry and biological applications

Y Zhao, TD Biggs, M Xian - Chemical communications, 2014 - pubs.rsc.org
… In this review we summarize the information about currently available H 2 S donors with a
focus on the chemistry of their development. Some biological applications are also discussed. …

Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

H Zhang, Z Bai, L Zhu, Y Liang, X Fan, J Li… - … of Medicinal Chemistry, 2020 - Elsevier
… of H 2 S donors, this review focuses on the most recent advances of therapeutic potential
of H 2 S donors in anti-atherosclerosis, especially synthetic organic donors, because sulfide …

Iminothioethers as hydrogen sulfide donors: from the gasotransmitter release to the vascular effects

E Barresi, G Nesi, V Citi, E Piragine… - … Medicinal Chemistry, 2017 - ACS Publications
… Ideal H 2 S donor drugs should produce H 2 S with relatively slow and constant rates. … 2
S-releasing chemical moieties suitable for the development of clinically effective H 2 S donors is …