… therapeutics, in which a dual-acting peptide engages two independent signalling pathways
resulting in superiority to single signalling pathway activation. This concept has been highly …

… To elucidate the magnitude of attenuation in the proteomic changes in heart failure by SS-peptides,
we plotted the fold change of the 538 significantly changed proteins in sham versus …

… with heart failure (4). Despite this profound drop in RBF, GFR is only slightly reduced in
untreated patients with heart failure … The increased filtration fraction in heart failure results in …

… peptide (NP) pathway is one key counter-regulatory system which is critical to the cardiovascular
system function generally and to the heart failure … in the NP pathway has accumulated, …

… [42] have proposed that, in chronic pathophysiological states such as hypertension or
congestive heart failure, a unique neuroendocrine milieu might lead to coordinated changes in the …

… Agents that target the GLP-1 pathway, including GLP-1 … effect of these agents on heart failure
outcomes in diabetics. To … to agents affecting the GLP-1 pathway (GLP-1 agonists and DPP…

… heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily
to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. … peptides, …

… Many aspects, however, still remain unclear as to the production, secretion and peripheral
degradation pathways of B- and C-type natriuretic peptides. In particular, the hypothesis that …

… peptide (NP) system has been extensively characterized and its potential influence in the
development and progression of heart failure … Both NPR-C and NEP pathways contribute to the …

… with pleiotropic effects, natriuretic peptide (NP) system includes … These peptides are genetically
distinct, but structurally and … NPs play central roles in regulation of heart failure (HF), and …