… publications on hepatic drug transporter DDIs using static models that tackle interactions
with individual transporters and in combination with other drug transporters and metabolising …

… hepatic transporter activity in health and disease. We cover mathematical modeling approaches
to obtain quantitative parameters of transporter … to evaluate hepatic transporter activity. …

… This approach is often associated with a shift in drug elimination processes from metabolic,
… A careful evaluation of individual transporters involved might allow reducing the risks …

… A key advantage of this approach is that since the membrane is ‘inside-out’ compounds do
… Several groups have successfully evaluated DDIs involving transporters using a range of …

… Existing challenges and approaches to examine the involvement of transporters in drug …
of disease state alterations in transporters (eg, altered hepatic transporters in underlying liver …

… It is evident that DDIs involving hepatic transporters are capable of … Areas covered: The role
of hepatic uptake transporters in drug … , evaluating the extent of DDIs associated with hepatic …

… This article provides an overview of different approaches to evaluate the hepatic transporters
involved in drug clearance. The advantages and limitations of the approaches were further …

… drug disposition by hepatic drug–metabolizing enzymes, predicting transporter-mediated …
, different approaches are often used to predict clearance with and without transporter …

… in new approaches for better prediction of transporter-… compounds as biomarkers for
transporter function, such as … III, or glycochenodeoxycholate sulfate for hepatic uptake via organic …

… approaches to evaluate the drug transporters involved in intestinal absorption, hepatic and
… the best practices to evaluate the major uptake and efflux transporters in drug discovery. It …