… As discussed in this review, the clinical relevance of other hepatic uptake transporters is
less clear, although OCT1 is an important mechanism for metformin distribution to the liver, and …

… of the clinically-relevant uptake transporter OATP1B1 affect cellular remdesivir uptake, …
it is a substrate of the additional important hepatic uptake transporters OATP2B1 and OCT1. …

… uptake ratio as a criterion to conduct follow- up clinical study.… thus active transport contribution
to hepatic clearance is limited, … there is clear preclinical evidence for hepatic uptake (eg, …

… The hepatic uptake clearance CL uptake is determined from the linear eq 1 (1)where X H(t)
is the amount of radioactivity found in the liver at time t, C blood(t) is the amount of the …

… This section covers the physiological and clinical relevance of albumin-mediated hepatic
uptake, with focus on how the alterations in albumin concentrations can influence the albumin-…

… This review describes the estimation of the contribution of OATP1B1 to the total hepatic
uptake of drugs from the data of fold-increases in the plasma concentration of substrate drugs by …

… On the basis of these observations, we postulate that when drugs do not require active
hepatic uptake to access the liver, there may be fairly insignificant differences in rat, dog, and …

… clinically relevant framework of non-invasive metabolic tests and their application in the
clinical … Additional findings for hepatic uptake systems have been obtained in rat liver perfusion …

… of the influence of active uptake and passive diffusion on hepatic clearance are presented.
The … of hepatic uptake are described, and their ability to predict hepatic clearance is reviewed. …

… clinical risks. Areas covered: The role of hepatic uptake transporters in drug disposition and
clinical … of victim drugs showing clinically relevant drug interactions, attributable to hepatic …