Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

YE Tian, V Cropley, AB Maier, NT Lautenschlager… - Nature medicine, 2023 - nature.com
aging network. We report organ age profiles for 16 chronic diseases, where advanced
biological aging extends from the organ of primary disease to multiple systems. Advanced body …

Characterizing the heterogeneity of aging: a vision for a staging system for aging

E Jaul, J Barron - Frontiers in Public Health, 2021 - frontiersin.org
… characterized by chronological age, functional status, chronic disease burden, … age strata
used in this study are obviously inexact, but useful. As noted, older adults are heterogeneous

Heterogeneous organ aging predicts chronic disease and mortality

Y Aman - Nature Aging, 2023 - nature.com
… hub, influenced by the aging of multiple other … aging profile for chronic diseases and mortality.
They identified that advanced biological aging extends from the organ of primary disease

Chronic disease projections in heterogeneous ageing populations: approximating multi-state models of joint distributions by modelling marginal distributions

RT Hoogenveen, PHM van Baal… - … medicine and biology …, 2010 - ieeexplore.ieee.org
disease stage, taking into account population heterogeneity and competing mortality risks.
The model is illustrated by presenting results of a scenario affecting disease … not included age

[HTML][HTML] Estimation of heterogeneity in diagnostic parameters of age-related diseases

D Blokh, I Stambler - Aging and disease, 2014 - ncbi.nlm.nih.gov
… validation on the chronic age-related disease samples may support … aging and chronic
diseases and a formal definition of aging and disease, as determined by particular heterogeneity (…

Health heterogeneity in older adults: exploration in the Canadian longitudinal study on aging

QD Nguyen, EM Moodie, MF Forget… - Journal of the …, 2021 - Wiley Online Library
… the heterogeneity due to differences between age groups with the heterogeneity due to
differences within age … features of heterogeneity in older adults, as a central tenet of aging, might …

Racial/ethnic differences in multimorbidity development and chronic disease accumulation for middle-aged adults

AR Quiñones, A Botoseneanu, S Markwardt, CL Nagel… - PloS one, 2019 - journals.plos.org
… Additionally, we excluded 369 respondents that identified as American Indian, Asian or “Other”
due to small and heterogeneous racial and ethnic categories that would have insufficient …

Successful aging: multiple trajectories and population heterogeneity

F Tang - Int'l J. Soc. Sci. Stud., 2014 - HeinOnline
aging trajectories in a sample of older Americans aged 65 and over (N=9,226). Six dimensions
were analyzed in the multi-trajectory model: chronic disease… diagnosed chronic diseases

Time trends in prevalence of chronic diseases and multimorbidity not only due to aging: data from general practices and health surveys

SH van Oostrom, R Gijsen, I Stirbu, JC Korevaar… - PloS one, 2016 - journals.plos.org
… The age distributions within the age category of 75 years and older may be heterogeneous
Therefore, future studies may divide the age category of 75 years and older in smaller age

Evaluating chronic disease for heterogeneous populations: the case of arthritis

RL Scharff, A Jessup - Medical care, 2007 - journals.lww.com
… We find that QALY losses from chronic arthritis vary by age, time since onset, and type of
arthritis. When we apply these results to prevention programs aimed at reducing the incidence …