… (A) The genome of the C68 chimpanzee adenovirus is schematically represented by the box
… C68 retains enough similarity to subgroup C adenoviruses to allow high-level replication of …

… In the present study, the majority (79%) of the fecal samples from 94 chimpanzees and 7
bonobos that were positive in the generic DPOL PCR belonged to HAdV-E, and from the …

… and were maintained at high levels through the remainder of the reporting period. Different
doses of vaccine were also tested in these trials, with the highest dose and broadest range of …

… of Y25 by another chimpanzee adenovirus belonging to Human adenovirus E, we used …
ChAd63 malaria vaccine developed extremely high neutralization titers against ChAd63 (>1∶…

… However, we have found only low-level cross-reacting antibody titers in the normal human …
the subgroup E chimpanzee adenoviruses was quite high among captive chimpanzees (data …

… Therefore the absence of high levels of liver transduction after systemic administration of
the chimpanzee adenoviral vectors was probably the cause of lower serum levels of A1AT after …

… One chimpanzee responded with a low-titered type-specific neutralizing antibody response
… and anti-adenovirus responses were enhanced. All three chimpanzees responded to the …

… The high levels of human morbidity and mortality during the last major outbreak in 2006/7
in eastern Africa underscores the urgency of developing comprehensive surveillance, …

… Here we show that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine
… of high-frequency TNF and IFN-γ coproducers combined with a fivefold higher level of triple-…

… Human sera have very little neutralizing activity against AdC7 and the E1 deleted virus,
generated from a molecular clone, is grown to high levels with no contamination with replication …