[HTML][HTML] The IL-2IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

J Damoiseaux - Clinical Immunology, 2020 - Elsevier
Increased levels of soluble (s)IL-2R, therefore, are considered as an indication of an on-…
high levels are encountered and are relevant for diagnosis and prognosis, respectively [1], [2]. …

Biological significance of soluble IL2 receptor

C Caruso, G Candore, D Cigna… - Mediators of …, 1993 - Wiley Online Library
… In transgenic mice constitutively producing high levels of IL-2… sIL-2R levels with tumour
burden, the high levelsof receptors … lymphoma cell lines have high levels of cellassociated IL-2R. …

Relationship of IL-2, IL-2R (CD25+), Soluble IL-2R and IL-4 with Disease Activity in SLE Patients

MJ Cuadrado, M Marubayashi, C Ortega… - Lupus, 1993 - journals.sagepub.com
… found that some patients with mild disease at the time of determination had higher level
than patients with severe activity. These results suggest that the immunosuppressive treatment …

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition.

JA Symons, NC Wood, FS Di Giovine… - Journal of immunology …, 1988 - journals.aai.org
… we wondered whether high levels of sIL-2R in synovial fluids … IL2 inhibition is associated
with immunoreactive sIL-2R … that sIL-2R protein mediates IL-2 inhibition by competing for IL-2. …

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses

LM Maier, DE Anderson, CA Severson… - The Journal of …, 2009 - journals.aai.org
… In contrast, we have shown that the MS risk alleles correlate with increased levels. Indeed,
a … . Expression of functional IL 2 receptors by lipopolysaccharide and interferon-γ stimulated …

Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases

MN Manoussakis, GK Papadopoulos, AA Drosos… - Clinical immunology and …, 1989 - Elsevier
… In this study, it was clearly demonstrated that increased levels of soluble IL-2R in the serum
… with the previously observed occurrence of high serum levels of soluble IL-2R, in various …

Increased soluble interleukin-2 receptor concentration in plasma predicts a decreased cellular response to IL-2

R Gooding, P Riches, G Dadian, J Moore… - British journal of …, 1995 - nature.com
… those patients receiving IL-2. A high concentration of soluble IL-2 receptor (sIL-2R) is commonly
… We investigated the possibility that high sIL-2R concentration pretreatment may interfere …

[PDF][PDF] Clinical significance of soluble interleukin-2 receptor measurement in immune-mediated diseases

WA Dik, M Heron - Neth J Med, 2020 - njmonline.nl
… -2Rα which enables these cells to constantly express the high-affinity trimeric IL-2R (IL-…
level of IL-2 as is present in vivo. 1 The high-affinity IL-2R is transiently expressed at high levels

High serum levels of soluble IL-2 receptor, cytokines, and C reactive protein correlate with impairment of T cell response in patients with advanced epithelial ovarian …

A Macciò, P Lai, MC Santona, L Pagliara, GB Melis… - Gynecologic …, 1998 - Elsevier
… [23], this study highlights the fact that circulating levels of IL-1α, IL-1ß, IL-6, TNFα, and sIL-2R
are significantly increased in cancer patients. This leads to the question concerning the cell …

Serum Levels of Soluble IL-2R, IL-4, and Soluble FcɛRII in Adult Bronchial Asthma

K Matsumoto, F Taki, K Takagi, M Miura, M Matsuzaki - Chest, 1994 - Elsevier
… made of serum levels of sIL-2R, IL-4, and sFcɛRII in adult asthmatics to confirm T-cell and
B-cell activation in the pathogenesis of asthma and elucidate the mode of involvement of IL-4 …