Nirmatrelvir plus ritonavir: first approval

YN Lamb - Drugs, 2022 - Springer
… , nirmatrelvir plus ritonavir received authorization in the EU for use in the same indication.
Nirmatrelvir plus ritonavir is … in the development of nirmatrelvir plus ritonavir leading to its first …

Nirmatrelvir plus ritonavir in COVID-19: a profile of its use

HA Blair - Drugs & Therapy Perspectives, 2023 - Springer
ritonavir acting as a pharmacokinetic booster. In the phase II/III EPIC-HR trial, nirmatrelvir
plus ritonavir reduced the risk of … -to-moderate COVID-19 at high risk for progression to severe …

Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir as treatments for COVID-19 in patients at high risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
… The analysis included all eligible recipients of molnupiravir and nirmatrelvir/ritonavir who …
or nirmatrelvir/ritonavir reduced the risk of hospitalization and death in this highly vulnerable …

Real-world effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab on preventing hospital admission among higher-risk patients with COVID-19 in Wales …

A Evans, C Qi, JO Adebayo, J Underwood, J Coulson… - Journal of Infection, 2023 - Elsevier
… A clinical access policy continues to support the treatment of higher-risk patients with … , and
nirmatrelvir-ritonavir in preventing hospital admission and death in higher-risk patients (Fig. 1) …

Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a real-world cohort of outpatients with COVID-19 at high risk of progression: the PISA …

G Tiseo, C Barbieri, V Galfo, S Occhineri… - Infectious Diseases and …, 2023 - Springer
… We found that patients treated with nirmatrelvir/ritonavir had a higher probability of having
a negative test within 10 days from the first positive one. This data may be affected by some …

Effectiveness of nirmatrelvir-ritonavir for the treatment of patients with mild to moderate COVID-19 and at high risk of hospitalization: systematic review and meta …

KM Souza, G Carrasco, R Rojas-Cortés… - Plos one, 2023 - journals.plos.org
… COVID-19 and eligible for nirmatrelvir-ritonavir treatment, a systematic review …
nirmatrelvir-ritonavir. The objective of this study was to evaluate the performance of …

Molnupiravir, nirmatrelvir/ritonavir, or sotrovimab for high-risk COVID-19 patients infected by the omicron variant: hospitalization, mortality, and time until negative …

L Cegolon, R Pol, O Simonetti, F Larese Filon… - Pharmaceuticals, 2023 - mdpi.com
… reduce viral shedding time (VST) in high-risk SARS-CoV-2 patients, … Nirmatrelvir/Ritonavir
in order to control VST in high-risk … on Nirmatrelvir/Ritonavir, the latter percentage increased to …

Real-world experience of the comparative effectiveness and safety of molnupiravir and nirmatrelvir/ritonavir in high-risk patients with COVID-19 in a community setting

Y Mutoh, T Umemura, T Nishikawa, K Kondo, Y Nishina… - Viruses, 2023 - mdpi.com
Molnupiravir (MOV) and nirmatrelvir/ritonavir (NMV/r) are efficacious oral antiviral agents for
patients with the 2019 coronavirus (COVID-19). However, little is known about their …

Nirmatrelvir plus ritonavir for early COVID-19 in a large US health system: a population-based cohort study

S Dryden-Peterson, A Kim, AY Kim… - Annals of internal …, 2023 - acpjournals.org
… coadministration of nirmatrelvir and ritonavir among vaccinated populations is uncertain.
This study emulated a clinical trial to assess whether nirmatrelvir plus ritonavir reduces risk for …

Comparative effectiveness of nirmatrelvir/ritonavir versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised high-risk …

B Zheng, J Tazare, L Nab, ACA Green… - The Lancet Regional …, 2023 - thelancet.com
… After adjusting for demographics, high-risk cohort categories, … in outcome risk between
nirmatrelvir/ritonavir and sotrovimab … the risks of severe outcomes between nirmatrelvir/ritonavir