… risk’ associated with individual variants into a single metric score has brought in a polygenic
risk score … of applications in psychiatry, including risk prediction, diagnosis, and prognosis (…

Purpose of Review The purpose of this review is to understand the conceptual basis and
implications of polygenic risk scores (PRS) in assessing risk of future coronary artery disease (…

… Summing the number of risk alleles weighted by their estimated effect sizes has also
been proposed as a method for computing multilocus genotype risk scores. Integrating risk …

… We next discuss how these studies can advance human health in the form of generating
leads for downstream mechanistic investigation or yielding polygenic risk scores (PRSs) for …

… with risk-prediction tools in the hope of improving their performance. A polygenic risk score
… to independently predict breast-cancer risk, and improved risk-prediction when incorporated …

… for mortality in critically ill adult patients and may complement existing risk prediction scores,
namely the APACHE II and the SAPS II score [84] . Another, less known but nevertheless …

… hype and, furthermore, direct-toconsumer (DTC) genetic testing could be misleading regarding
cancer risk. In … screening by highlighting both the hope and hype of its clinical application. …

… an adopted risk score based on the variables identified in this study as a predictive model. …
This study demonstrates that risk scores are of limited suitability to identify patients who are …

… risk score is associated with a 24% higher relative risk of HF within 5 years. The WATCH-DM
risk score … Both the risk score and the RSF-based risk prediction model were externally …

… the polygenic risk scores to a variety of diseases [9,10]. For cardiology, the risk score has
been … Usage of polygenic risk scores and genetic profiling is not limited to phenotypic …