Extended-Infusion β-Lactam Therapy, Mortality, and Subsequent Antibiotic Resistance Among Hospitalized Adults With Gram-Negative Bloodstream Infections

SM Karaba, SE Cosgrove, JH Lee, S Fiawoo… - JAMA Network …, 2024 - jamanetwork.com
… A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe
… We identified a survival benefit among adult patients with GN-BSI receiving EI-BL compared …

Respiratory fluoroquinolone monotherapy versus β-lactam plus macrolide combination therapy for hospitalized adults with community-acquired pneumonia: A …

SH Choi, A Cesar, TAC Snow, N Saleem… - International Journal of …, 2023 - Elsevier
… Guidelines recommend respiratory fluoroquinolone monotherapy or β-lactam plus macrolide
combination therapy as first-line options for hospitalized adults with mild to moderate …

Antibiotic therapy for adults hospitalized with community-acquired pneumonia: a systematic review

JS Lee, DL Giesler, WF Gellad, MJ Fine - Jama, 2016 - jamanetwork.com
… ) hospitalized during 3 separate years reported that β-lactam … in adults of all ages also
reported that various β-lactam plus … -term mortality compared with β-lactam monotherapy. Only a …

[HTML][HTML] Fluoroquinolones or macrolides in combination with β-lactams in adult patients hospitalized with community acquired pneumonia: a systematic review and …

KZ Vardakas, KK Trigkidis, ME Falagas - Clinical Microbiology and …, 2017 - Elsevier
… option for hospitalized patients with community-acquired pneumonia (CAP) has not been
defined. The effectiveness of β-lactam/fluoroquinolone (BLFQ) versus β-lactam/macrolide (BLM…

Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection—a prospective observational study

M Hatti, N Solomonidi, I Odenholt, J Tham… - European Journal of …, 2018 - Springer
… suggested [30], but in older adults, significantly increased risk of adverse events … lactam
antibiotics do not provide predictable trough antibiotic concentrations in older adults hospitalized

Impact of intravenous β-lactam/macrolide versus β-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia

A Tessmer, T Welte, P Martus, M Schnoor… - Journal of …, 2009 - academic.oup.com
… Guidelines recommend dual-therapy consisting of a β-lactam/macrolide (BLM) for hospitalized
patients with community-acquired pneumonia. Nevertheless, the superiority over β-lactam

Development and assessment of risk scores for carbapenem and extensive β-lactam resistance among adult hospitalized patients with Pseudomonas aeruginosa …

SY Tartof, JL Kuntz, LH Chen, R Wei… - JAMA network …, 2018 - jamanetwork.com
… and EBR among hospitalized adult patients with P … adult hospitalized patients were CR.
More alarmingly, nearly 10% of P aeruginosa infections were resistant to most of the β-lactam

Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost

EA King, S Challa, P Curtin, L Bielory - Annals of Allergy, Asthma & …, 2016 - Elsevier
… A retrospective analysis was conducted on adult inpatients with a β-lactam allergy who …
The primary outcome was overall antibiotic cost savings for patients switched to a β-lactam

β-Lactam monotherapy vs β-lactam–macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial

N Garin, D Genné, S Carballo, C Chuard… - JAMA internal …, 2014 - jamanetwork.com
… noninferiority of β-lactam monotherapy in patients hospitalized for … β-lactam monotherapy
was noninferior to the combination of a β-lactam and a macrolide in adult patients hospitalized

… adult hospitalized patients with carbapenem-resistant Gram-negative infections who received targeted treatment with a newer β-lactam or β-lactam/β-lactamase …

TP Lodise, E Yucel, EN Obi… - Journal of …, 2024 - academic.oup.com
… used antibiotics among adult, hospitalized patients with … hospitalized adult patients
with CR-GNIs who received targeted treatment with a newer β-lactam or β-lactam/β-lactamase