[HTML][HTML] Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection

AZ Wec, ZA Bornholdt, S He, AS Herbert, E Goodwin… - Cell host & …, 2019 - cell.com
antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD).
However, all mAbs and mAb cocktails … , a cocktail of two broadly neutralizing human mAbs, ADI-…

[HTML][HTML] Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

H Yao, Y Sun, YQ Deng, N Wang, Y Tan, NN Zhang… - Cell research, 2021 - nature.com
cocktail against SARS-CoV-2. On the basis of our previously identified humanized cross-neutralizing
antibody H014, we systematically analyzed a fully human naive antibody library …

Antibody cocktails: next-generation biopharmaceuticals with improved potency

T Logtenberg - TRENDS in Biotechnology, 2007 - cell.com
antibodies, and places an emphasis on antibody cocktails that seek to mimic the potency of
natural polyclonal-antibodyhuman antibodies, and pooled sera might be used to prepare …

[HTML][HTML] REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients with
Covid-19, we investigated two fully human, neutralizing monoclonal antibodies against severe …

[HTML][HTML] Structure-based development of human antibody cocktails against SARS-CoV-2

N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
antibody cocktail therapeutics for Ebola were generated by mixing NAbs from humanized
antibodies from mice and human … critical roles in the design of antibody cocktails, and that this …

First administration to humans of a monoclonal antibody cocktail against rabies virus: safety, tolerability, and neutralizing activity

ABH Bakker, C Python, CJ Kissling, P Pandya… - Vaccine, 2008 - Elsevier
… monoclonal antibody cocktail CL184 against rabies. … human monoclonal antibody (mAb)
cocktail, CL184, which consists of two mAbs (CR57, human IgG1 lambda and CR4098, human

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
… Inclusion of such antibodies into an antibody cocktail … an antibody-based therapeutic for
treatment and prevention of COVID-19. Such an antibody cocktail is now being tested in human

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… , individually as well as when combined into cocktails. These antibodies remain effective
against spike variants that have arisen in the human population. However, novel spike mutants …

[HTML][HTML] Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization

P Gilchuk, CD Murin, JC Milligan, RW Cross, CE Mire… - Immunity, 2020 - cell.com
antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to
develop a therapeutic mAb cocktail … analyzed the antibody repertoire in human survivors and …

A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

J de Kruif, ABH Bakker, WE Marissen… - Annu. Rev …, 2007 - annualreviews.org
… used to guide development of a cocktail of human monoclonal antibodies as a replacement
for RIG. … Therefore, we conclude that the human mAb cocktail CR57/CR4098 is a safe and …