… with mouse MAbs to better understand the human antibody response. The human antibody
… human antibody response to DENV infection and identify important gaps in our knowledge. …

… heavy- and light-chain loci will result in reproduction of the human antibody response to
infection and immunization. Delivery of megabase Ig gene fragments, which should be possible …

… antibodies isolated after natural infection bound broadly to current and historic virus strains,
inhibited NA activity and provided protection in an antibody transfer challenge study in mice …

… small animal models for these infections hinders the in vivo … technology (a mouse that
expresses human antibody-variable … mouse genome) to quickly develop and evaluate antibodies …

… of the original mouse antibody and the reshaped human antibody to clear an established
infection in BALB/c mice, when administered intraperitoneally on day 4 of infection, is shown in …

… We found that adult HIS mice created as described above can be infected with the bacteria
… these mice can be adapted to make them effective models for human antibody responses to …

… To develop candidate therapeutic agents against ZIKV, we isolated a panel of human
monoclonal antibodies from subjects that were previously infected with ZIKV. We show that a …

… for a therapeutic antibody. To generate a clinically useful therapeutic monoclonal antibody
(… (17, 18) to clone high-affinity native human MAbs that bind to DNABII homologs from diverse …

… demonstrated in normal neonatal humans (9, IO). … mice can be protected from fatal HSV
infection by a combination of small amounts of human antiviral antibody and nonimmune human …

… to PC would be able to protect mice against S. pneumoniae freshly isolated from humans. In
… G (IgG) monoclonal antibody (MAb) to PC to protect against infections in mice caused by 14 …