Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
human proteases as entry activators. Using biochemical and pseudovirus entry assays and
SARS-CoV as a comparison, we have identified key cell … studies on cell entry of SARS-CoV-2…

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… We describe how SARS-CoV-2 may infect the lower respiratory tract and cause … cells
targeted by SARS-CoV-2 during natural infection in humans are likely to be multiciliated cells

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - … reviews Molecular cell …, 2022 - nature.com
… the structural and cellular foundations for understanding the multistep SARS-CoV-2 entry …
and S protein adaptations that facilitate efficient human transmission. We also examine the …

Coronaviruses and sars-cov-2

M Hasöksüz, S Kilic, F Saraç - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
… To gain entry into human cells, many α coronaviruses (HCoV-229E, TGEV, PEDV, FIPV… cell
culture [46,47]. It is also believed that SARSCoV was transmitted from palm civets to humans

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

S Temmam, K Vongphayloth, E Baquero, S Munier… - Nature, 2022 - nature.com
… to SARS-CoV-2 whose RBDs differ from that of SARS-CoV-2 … human cells. Despite the
absence of the furin cleavage site, these viruses may have contributed to the origin of SARS-CoV-…

Cell entry by SARS-CoV-2

R Peng, LA Wu, Q Wang, J Qi, GF Gao - Trends in biochemical sciences, 2021 - cell.com
… virus 2 (SARS-CoV-2) invades host cells by interacting … cellular membranes. The host
membrane protein, angiotensin-converting enzyme 2 (ACE2), is the major receptor for SARS-CoV-…

[HTML][HTML] Identification of required host factors for SARS-CoV-2 infection in human cells

Z Daniloski, TX Jordan, HH Wessels, DA Hoagland… - Cell, 2021 - cell.com
SARS-CoV-2 infects A549 ACE2 cells by staining for the nucleocapsid (N) protein at 24 h
post-infection (Figure 1B), and at day 6 post-infection, we measured cell … surviving cells at day …

Structural and functional basis of SARS-CoV-2 entry by using human ACE2

Q Wang, Y Zhang, L Wu, S Niu, C Song, Z Zhang, G Lu… - Cell, 2020 - cell.com
… receptor for SARS-CoV-2. In this study, we present the crystal structure of the C-terminal
domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (…

SARS-CoV-2 productively infects human gut enterocytes

MM Lamers, J Beumer, J van der Vaart, K Knoops… - Science, 2020 - science.org
… This study shows that SARS-CoV and SARS-CoV-2 infect enterocyte lineage cells in an
hSIO model. We observed similar infection rates of enterocyte precursors and enterocytes, …

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

N Zhu, W Wang, Z Liu, C Liang, W Wang, F Ye… - Nature …, 2020 - nature.com
SARS-CoV and HCoV-NL63 by using the same receptor 10,11 . To further confirm the tropism
of SARS-CoV… , we found that SARS-CoV-2 infects both ciliated cells and secretory cells. As …