… by current gene constraint metrics. We demonstrate that this genome-wide constraint
map improves the identification and interpretation of functional human genetic variation. …

… Employing similar logic, we sought to identify localized, highly constrained coding regions
(CCRs) in the human genome. We were motivated by the idea that the absence of genetic …

… underrecognized by gene constraint metrics. We demonstrate that this genome-wide
constraint map provides an effective approach for characterizing the non-coding genome and …

… interpreting functional elements in the human genome on the basis of their … constraint
using 29 eutherian (placental) genomes. We identify 4.2% of the human genome as constrained …

… human genome has been constrained by the limited resolution and accuracy of existing genetic
maps and the draft genome … , to build a high-resolution genetic map meant to: (i) improve …

… the human genome. Here, we present orthologous sequence generation, alignment, and
evolutionary constraint … This map was used to “undo” the genomic rearrangements of the other …

Author Correction: A genomic mutational constraint map using variation in 76,156 human
genomes | Nature … National Human Genome Research Institute, National Institutes of …

… human traits, including diseases 9,14,24,41 . The aim of this Analysis is to create a CNV map
of the human genome for … This CNV map has been generated with certain constraints. First, …

… majority of variants at functionally constrained sites in human genomes is noncoding. …
Evolutionary constraint may also be of use in the fine-mapping of causative alleles after an …

… genomes of 1,092 individuals from 14 populations, constructed using a combination of
low-coverage whole-genome … sources we provide a validated haplotype map of 38 million SNPs, …