Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes

NE Fusenig, P Boukamp - … in cooperation with the University of …, 1998 - Wiley Online Library
tumor suppressor genes, eg, on chromosome 9 as in human … as phenotypic stages involved
in the process of human skin … of mutant p53 into human keratinocytes has failed to induce …

Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo

NE Fusenig, D Breitkreutz, RT Dzarlieva… - Journal of Investigative …, 1983 - Elsevier
phenotypic alterations in growth and differentiation of mouse and human malignant skin
keratinocytes… , and this was particularly the case for a human keratinocyte tumor line (Table II). …

Deficiency in catalase activity correlates with the appearance of tumor phenotype in human keratinocytes

T Rabilloud, D Asselineau, C Miquel… - … journal of cancer, 1990 - Wiley Online Library
… to the intensity of tumor phenotype expression, … keratinocyte cell lines allowed us to test
our hypothesis that catalase decline correlates with progressive acquisition of tumor phenotype

Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

MM Mueller, NE Fusenig - Differentiation, 2002 - Elsevier
… correlates with a largely stable chromosome content during long-term culture of the
human keratinocyte line HaCaT. Genes, Chromsomes & Cancer 19:201–214. Boukamp, P., …

Characterization of human keratinocyte

DM Peehl, EJ Stanbridge - International Journal of Cancer, 1981 - Wiley Online Library
phenotype, we have now produced hybrids from fusions between HeLa and normal human
… The key question is whether these nodules represent bona fide tumors or whether they are …

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.

PJ Hurlin, P Kaur, PP Smith… - Proceedings of the …, 1991 - National Acad Sciences
… lacked the malignant phenotype of later passage S3 cells. It is likely, therefore, that the cells
that produced tumors that regressed represented an intermediate phenotype and that these …

Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes

H Strnad, L Lacina, M Kolář, Z Čada, Č Vlček… - Histochemistry and cell …, 2010 - Springer
… prepared from the tumor stroma on keratinocytes and the … of phenotype of keratinocytes
cocultured with cancer stroma-associated fibroblasts, we evaluated the keratinocyte phenotypic

Induced expression of dominant‐negative c‐jun downregulates NFκB and AP‐1 target genes and suppresses tumor phenotype in human keratinocytes

JJ Li, Y Cao, MR Young… - … : Published in cooperation …, 2000 - Wiley Online Library
… responsive to AP-1 and dramatically suppressed tumor phenotype in human keratinocytes.
human keratinocytes in the present study. This humanversus-mouse keratinocyte

Fibroblasts isolated from the malignant melanoma influence phenotype of normal human keratinocytes

J Kučera, B Dvořánková, K Smetana Jr, P Szabo… - journal of applied …, 2015 - Elsevier
keratinocytes, is limited. In this, study we tested the effect of fibroblasts isolated from malignant
melanoma on phenotype of normal human keratinocytes, … and their role in tumor biology. …

[HTML][HTML] The magnitude of hedgehog signaling activity defines skin tumor phenotype

V Grachtchouk, M Grachtchouk, L Lowe… - The EMBO …, 2003 - embopress.org
… are associated with different epithelial tumor types in the skin of mice and humans, and
provide … in humans BCCs, our findings argue that expression of M2SMO in keratinocytes is not …