[HTML][HTML] Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

F Awad, E Assrawi, C Jumeau, S Georgin-Lavialle… - PloS one, 2017 - journals.plos.org
… expression of NLRP3 inflammasome components in PBMCs, monocytes and macrophages.
… We then tested cytokine secretion during NLRP3 inflammasome activation in M0, M1 or M2 …

[HTML][HTML] Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

K Rajamäki, J Lappalainen, K Öörni, E Välimäki… - PloS one, 2010 - journals.plos.org
… Here we show that human macrophages avidly phagocytose … IL-1β from human monocytes
and macrophages. The cholesterol … of an inflammasome-mediated pathway. Silencing of the …

Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages

O Lunov, T Syrovets, C Loos, GU Nienhaus… - ACS …, 2011 - ACS Publications
inflammasomes were not activated by PS-NH 2 . The PS-NH 2 -mediated proinflammatory
macrophage … Our study reveals the molecular mechanism of NLRP3 inflammasome activation …

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

MM Budai, A Varga, S Milesz, J Tőzsér, S Benkő - Molecular immunology, 2013 - Elsevier
… that of the components of Nlrp3 inflammasome in LPS-activated macrophages. We have …
on human macrophage-like THP-1 cells as well as on human monocyte-derived macrophages. …

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

X Wang, WJ Eagen, JC Lee - Proceedings of the National …, 2020 - National Acad Sciences
… Staphylococcus aureus are internalized by human macrophages by an endocytic process, …
Macrophages incubated with S. aureus EVs undergo NLRP3 inflammasome activation that is …

Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages

AM Riestra, JA Valderrama, KA Patras… - Journal of innate …, 2018 - karger.com
NLRP3 inflammasome activation in human macrophages, … Using inhibitor-based approaches,
we show that NLRP3 activation … vaginalis inflammasome activation induces macrophage in…

[HTML][HTML] NLRP3 licenses NLRP11 for inflammasome activation in human macrophages

A Gangopadhyay, S Devi, S Tenguria, J Carriere… - Nature …, 2022 - nature.com
NLRP3 inflammasome component in human macrophages. NLRP11 bound to ASC and
NLRP3 and was required for NLRP3 … In the absence of NLRP11, NLRP3-mediated caspase-1 …

[HTML][HTML] β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies

G Camilli, M Bohm, AC Piffer, R Lavenir… - The Journal of …, 2020 - Am Soc Clin Investig
… of β-glucan on NLRP3 inflammasome activation in macrophages generated from healthy …
NLRP3 inflammasome activation in patients with gain-of-function mutations in the NLRP3 gene…

Charcot–Leyden crystals activate the NLRP3 inflammasome and cause IL-1β inflammation in human macrophages

JF Rodríguez-Alcázar, MA Ataide, G Engels… - The Journal of …, 2019 - journals.aai.org
… Our findings reveal that CLCs are recognized by the NLRP3 inflammasome, … for NLRP3
inflammasome assembly in vitro and in vivo. Whereas in our in vitro system human macrophages

Human NLRP3 inflammasome senses multiple types of bacterial RNAs

W Sha, H Mitoma, S Hanabuchi… - Proceedings of the …, 2014 - National Acad Sciences
… the NLRP3 inflammasome in human macrophages but not in murine macrophages. Therefore,
… In this study, we show that human macrophages sense all bacterial RNA components (…